DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and MEIS3

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	XP_024307380.1	Gene:	MEIS3 / 56917	HGNCID:	29537	Length:	509	Species:	Homo sapiens

Alignment Length:	283	Identity:	64/283 - (22%)
Similarity:	92/283 - (32%)	Gaps:	127/283 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 YPSNEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWT----SASLQSTTGYYSYD----- 212
            ||::    .||:         |..|...|:|...|..:...|    |..|.|.:|..|.|
Human   277 YPAS----CPSL---------PDQNNMWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGL 328

  Fly   213 --PTLAAYGYGPNYDL-AARRKNATR-----ESTATLKAWLSEH--------------------- 248
              ...:....|.:.|| ..||:|..|     .:|..::|||.:|
Human   329 DTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPS 393

  Fly   249 -------------------------KKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 288
                                     .::|||::.:|..||..|.:|:.||:.||.|||||:.:.
Human   394 PGPRWARPWGSDCGRPGRQSDSCWWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQP- 457

  Fly   289 KMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLD 353
              ..:..|:|                 |.|.     ||.|..|.|.   |..|
Human   458 --MIDQSNRT-----------------GQGA-----AFSPEGQPIG---GYTE------------ 483

  Fly   354 LDREPHNLVAMRGLAPYATPPGA 376
              .:||  ||:|       |||:
Human   484 --TQPH--VAVR-------PPGS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	18/84 (21%)
caup	NP_524046.2	IRO	455..472	CDD:214716
MEIS3	XP_024307380.1	Meis_PKNOX_N	184..267	CDD:318653
MEIS3	XP_024307380.1	Homeobox_KN	417..453	CDD:310480	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900