DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and PKNOX1

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_004562.2	Gene:	PKNOX1 / 5316	HGNCID:	9022	Length:	436	Species:	Homo sapiens

Alignment Length:	239	Identity:	56/239 - (23%)
Similarity:	85/239 - (35%)	Gaps:	74/239 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LSSAAQDLPSRGSCC-------------ENGRPIITDPVSGQTVCSC---QYDPARLAIGGYSRM 141
            ::...:|..||...|             |.|.|.  .||..|.:.|.   ...|..:.:   ...
Human   135 VNELCKDFCSRYIACLKTKMNSETLLSGEPGSPY--SPVQSQQIQSAITGTISPQGIVV---PAS 194

  Fly   142 ALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPLS--NPYG---IKDTSPSTEMSAWTSAS 201
            ||..|.|.:....|                 ...|.|::  .|.|   .:..||.|.....:...
Human   195 ALQQGNVAMATVAG-----------------GTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQ 242

  Fly   202 LQSTTGYYSYDPTLAAYGYGPNYDLAA----------RRKNATRESTATLKAWLSEHKKNPYPTK 256
            ||.                  |.||:.          :|....:.:|..:::||.:|..:||||:
Human   243 LQL------------------NQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTE 289

  Fly   257 GEKIMLAIITKMTLTQVSTWFANARRRLKK---ENKMTWEPKNK 297
            .||..:|..|.:||.||:.||.|||||:.:   ::..:..||.|
Human   290 DEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	20/38 (53%)
caup	NP_524046.2	IRO	455..472	CDD:214716
PKNOX1	NP_004562.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Meis_PKNOX_N	80..165	CDD:406806	5/29 (17%)
		Homeobox_KN	277..316	CDD:399131	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900