DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and Irx4

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_061373.1	Gene:	Irx4 / 50916	MGIID:	1355275	Length:	515	Species:	Mus musculus

Alignment Length:	572	Identity:	177/572 - (30%)
Similarity:	233/572 - (40%)	Gaps:	149/572 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SSAAQDLPSRGS---CCENGRPIITD---PVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGV 152
            |||.|.|.:..|   |||:|...:.|   ..|.|....|....:||.  ..:|..|.| ...:||
Mouse    11 SSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLL--ATARHELNS-AAALGV 72

  Fly   153 YGGPYPSNE-QNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQST--TGYYSYDPT 214
            ||.||.|:: ...|.:.|.:.||||:  .|.:..||.:.|:.      |.|..|  ..||.|:|.
Mouse    73 YGSPYGSSQGYGNYVTYGSEASAFYS--LNSFESKDGTGSSH------AGLPPTAAAAYYPYEPA 129

  Fly   215 LAAYGYG--PNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWF 277
            |:.|.|.  ...|...||||||||:|:||||||.||:||||||||||||||||||||||||||||
Mouse   130 LSQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWF 194

  Fly   278 ANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSE--LGKA 340
            |||||||||||||||.|:||..|:.......:|:|  ||:     .|:.:...:..|||  .||.
Mouse   195 ANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEE--AGE-----EESREEPLKSAKSEGHAGKD 252

  Fly   341 EKEVDSSGDQKLD-LDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHH 404
            :||::.|..:..| ||.|..............:.|...|..:......:..:|
Mouse   253 DKELELSDLEDFDPLDAETSECELKTPFQSLDSGPERIPASSDGPGTGKEAST------------ 305

  Fly   405 QQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIP-------VPA----- 457
                            .:..|....||...:  |:....:|.|.....:|       .||
Mouse   306 ----------------TLRMPLGTAGGAVMD--GDLERARNCLRSTVVVPDSGAEGGPPACEAKL 352

  Fly   458 ------------SKPKIWSVADTAACKTPPPTAAYLGQNFY-----------------PPSSADQ 493
                        :||:|||:|.||..    ..|..|.|..:                 |.||...
Mouse   353 TFAQAGAPPNLETKPRIWSLAHTATA----AAATALSQTEFPSCMLKRQGPTGVSATTPASSPAV 413

  Fly   494 QLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGG---SP---YSRIP 552
            ..|...|.:||.                            ||::.:.::..|   .|   :|.:.
Mouse   414 TAPSGALDRHQD----------------------------SPVTSLRNWVDGVFHDPILRHSTLN 450

  Fly   553 TAYTEAMGMHL-PSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQPDTPPQTPP 603
            .|:..|.|..| |.....:...|    |::...|....||   |..|...||
Mouse   451 QAWATAKGALLDPGPLGRNLGAG----TNVLTTPLACSFP---PTVPQDVPP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	10/33 (30%)
Irx4	NP_061373.1	Homeobox_KN	161..200	CDD:368670	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..258		21/59 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..307		3/56 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..425		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8243
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8793
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.880