Protein Alignment caup and IRX4

DIOPT Version :9

• Sequence 1: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Sequence 2: NP_001265562.1
• Gene: IRX4 / 50805
• HGNCID: 6129
• Length: 545
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 185/620 - (29%)
• Similarity: 242/620 - (39%)
• Gaps: 191/620 - (30%)

  Fly    94 SSAAQDLPSRGS---CCENGRPIITD---PVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGV 152
            |||.|.|.:..|   |||:|...:.|   ..|.|....|....:||.  ..:|..|.| ...:||
Human    11 SSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLL--ATARHELNS-AAALGV 72

  Fly   153 YGGPYPSNE-QNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLA 216
            |||||..:: ...|.:.|.:.||||:  .|.:..||.|.|.......:|:     .||.|:|.|.
Human    73 YGGPYGGSQGYGNYVTYGSEASAFYS--LNSFDSKDGSGSAHGGLAPAAA-----AYYPYEPALG 130

  Fly   217 AYGY-------------------------GPNY---DLAARRKNATRESTATLKAWLSEHKKNPY 253
            .|.|                         |..|   |...||||||||:|:||||||.||:||||
Human   131 QYPYDRIKRLGGHPHKGIGLDLSGLGRSPGSLYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPY 195

  Fly   254 PTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEK---EKDA 315
            |||||||||||||||||||||||||||||||||||||||.|:||..|:.......:|:   |::|
Human   196 PTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEA 260

  Fly   316 GDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLD-LDREP---------HNLVAMRGLAPY 370
            .:....|::..:|        :||.|||::.|.....| |:.||         |:|.......|
Human   261 REEPLKSSKNAEP--------VGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVP- 316

  Fly   371 ATPPGAHPMHAAYSSYAQS--------------------HNTHTHPHPQQMQHHQQQQQQQQNQQ 415
            |.|.|  |:..|..:...|                    .:....|.|.
Human   317 AAPDG--PVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPL---------------- 363

  Fly   416 QLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAACKTPPPTAAY 480
                         ||..|..:..|......|.....|:   .:||:|||:|.||.......|:
Human   364 -------------PGAEGGPQVCEAKLGFVPAGASAGL---EAKPRIWSLAHTATAAAAAATS-- 410

  Fly   481 LGQNFYPPSSADQQ-------------------LPHQ-PLQQHQQQQLQQLQQQQQHHHHPHHHH 525
            |.|..:|.....:|                   |||. .|.:||.
Human   411 LSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQD-------------------- 455

  Fly   526 PHHSMELGSPLSMMSSYAGG---SP---YSRIPTAYTEAMGMHL-PSSSSSSSSTGKLPPTHIHP 583
                    ||::.:.::..|   .|   :|.:..|:..|.|..| |.....|...|    .::..
Human   456 --------SPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAG----ANVLT 508

  Fly   584 APQRVGFPEIQPDTPPQTPPT------MKLNSSGG 612
            ||....||   |..|...|..      :.|..:||
Human   509 APLARAFP---PAVPQDAPAAGAARELLALPKAGG 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
		IRO	455..472	CDD:214716	8/16 (50%)
IRX4	NP_001265562.1	Homeobox_KN	186..225	CDD:368670	36/38 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8271
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3917
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8566
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.970