DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caup and irx2

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_001008113.1	Gene:	irx2 / 493475	XenbaseID:	XB-GENE-480618	Length:	456	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	163/529 - (30%)
Similarity:	210/529 - (39%)	Gaps:	135/529 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PVSGQTVCSC-QYDPARLAIGGYSRMALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPL- 179
            |.....:.|| .|..:.||......:|..|.|.....|.|......|..        :.|.:||
Frog    11 PPGSLALYSCPAYGASALAAPRSEELARSSSGSAFSPYPGSAAFTAQAA--------TGFSSPLQ 67

  Fly   180 --SNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDP-TLAAYGYGPNYDLAARRKNATRESTATL 241
              |:|.|.    || .|.:...|.....||..||.| ..|||.|..|.  .|.||||||::||||
Frog    68 YSSDPAGF----PS-YMGSPYDAHTTGMTGALSYHPYGSAAYPYQLND--PAYRKNATRDATATL 125

  Fly   242 KAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMM 306
            ||||.||:|||||||||||||||||||||||||||||||||||||||||||.|:||:||:||
Frog   126 KAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKSEDEDD--- 187

  Fly   307 SDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKE-----VDSSGDQKLDLDREPHNLVAMRG 366
                   |.|||.::..|..:......::   .||.|     |||..|.....|.:...|
Frog   188 -------DEGDGERVKEEQSEKAQDCNET---SAEDEGISLHVDSLTDHSCSADSDGEKL----- 237

  Fly   367 LAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQ--------------- 416
                       |..|.      .|...:....::.....:.:::...:.:
Frog   238 -----------PCRAT------DHLCESGSESKEKYDDDEDEEEGDEEDRVLPVKPATSSPLTGV 285

  Fly   417 ----LQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGI----PVPASKPKIWSVADTAACKT 473
                |.|.|...|                ...|..|.|.|:    ..||||||:||:|:.|   |
Frog   286 EAPILNHQQDGSP----------------RNSNKTSLDNGMSPSSQTPASKPKLWSLAEIA---T 331

  Fly   474 PPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHS--MELGSPL 536
            .....:.||...   |||.....|.|  .:....|.        ..|.::..|.:|  ...|:..
Frog   332 SDHKHSNLGSVL---SSATSSAAHNP--SYPSSSLL--------GRHIYYTSPFYSNYTNYGNFN 383

  Fly   537 SMMSSYAGGSPYSRIPTAYTEAM--------GMHLPSSSSSSSSTGKLPPTHIHPA-------PQ 586
            ::.|.  |...||.......|.:        .||..:|.|..:::.:| ..|..|.       |.
Frog   384 ALQSQ--GILRYSSAAVTANEGLNQTVLSTSSMHKHTSDSVRTASNQL-DQHYRPTNFESKKDPS 445

  Fly   587 RVGFPEIQP 595
            .|....:||
Frog   446 EVCTVGVQP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	10/16 (63%)
irx2	NP_001008113.1	COG5576	<110..212	CDD:227863	72/116 (62%)
		Homeobox_KN	128..167	CDD:368670	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..214		19/54 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..320		10/89 (11%)
		IRO	317..333	CDD:214716	11/18 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..456		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8124
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010