DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and irx6a

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	XP_005169033.1	Gene:	irx6a / 474317	ZFINID:	ZDB-GENE-040712-5	Length:	505	Species:	Danio rerio

Alignment Length:	550	Identity:	171/550 - (31%)
Similarity:	232/550 - (42%)	Gaps:	137/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SCCEN-GRPIITDPVSGQTV---CSCQYDPARLAIGGYSRMALPSGGVGVGVYGGPYPS------ 159
            :||:: .|.:.....:.||.   |...|:...||   .:|..|   ...:|:||.||.:
Zfish    32 TCCDSISRSVTEGSSASQTAASFCCPSYENRLLA---STRTEL---NAALGMYGSPYAAAAAAAG 90

  Fly   160 -NEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQST----TGYYSYDPTLAAYG 219
             |..|.:| ...|.||.|:.|:..|.||:          .|.||.||    ..||.||.:|..|.
Zfish    91 QNYANYFP-YSADPSAIYSSLNPQYEIKE----------GSGSLHSTITQPATYYPYDHSLGQYQ 144

  Fly   220 YG----PNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANA 280
            |.    .:::.:.||||||||:|:|||.||.||:|||||||||||||||||||||||||||||||
Zfish   145 YDRYGTVDFNGSTRRKNATRETTSTLKTWLYEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANA 209

  Fly   281 RRRLKKENKMTWEPKNKTEDD--DDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKE 343
            ||||||||||||.||||..||  :|...||.:..||:.|........|...:.:...:..|.:.:
Zfish   210 RRRLKKENKMTWSPKNKAGDDRKEDLGKSDPDITKDSKDSKDEQDLQFSDLDDMEDEDCDKLDSD 274

  Fly   344 VDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAH-----PMHAAYSSYAQSHNTHTHPHPQQMQH 403
            .:.||...|                |.::||...     |:|:.:.|:.....:....:|..:.|
Zfish   275 CEKSGQDDL----------------PTSSPPKRDCNPDIPLHSNFPSFPCGLKSLGPLNPDYLDH 323

  Fly   404 HQQQQQQQQ--------NQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKP 460
            ...:.||||        |...|.|.               ||.|                   ||
Zfish   324 LGSKPQQQQPSPQSTSINTVALSHF---------------ESSE-------------------KP 354

  Fly   461 KIWSVADTAACKTPPPTAAYLGQNFYPPSSADQQLPHQP----LQQHQQQQLQQ----------L 511
            :|||:|.|||......| .::|.....|.....|....|    :|..:.:.||.          .
Zfish   355 RIWSLARTAAAGVVLGT-QHVGDVRTGPVDCQMQGVRLPTVGAVQCGELKGLQDPTNLSNTESLF 418

  Fly   512 QQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSSTGKL 576
            |:..|..|..:......:::|.|     |||.|.:...:    |:...|  .||:..:.:.:.:|
Zfish   419 QEGLQGIHKAYSSGSFKTLQLHS-----SSYPGLTESCQ----YSSMEG--FPSAGKTETESSEL 472

  Fly   577 PPTHIHPAPQRVGFPEIQPDTPPQTPPTMK 606
            ..|          .|.||........|.||
Zfish   473 SDT----------CPTIQEAKTTAFRPVMK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	9/16 (56%)
irx6a	XP_005169033.1	Homeobox_KN	173..212	CDD:283551	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4024
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.930