Protein Alignment caup and MEIS2

DIOPT Version :9

• Sequence 1: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Sequence 2: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 104/483 - (21%)
• Similarity: 157/483 - (32%)
• Gaps: 144/483 - (29%)

  Fly    47 GGSTATGLTAG----PLSPGAVSQSSH-------HAGHKGLSTSPAEDVVGGDVPVGLSSAAQDL 100
            ||....|:.|.    |.:|..:....|       ||.....:.:|..:|    :|..:.||..|.
Human    12 GGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNV----MPASMGSAVNDA 72

  Fly   101 PSRGSCCENGRPIITDPVSGQTVCSCQY---DPARLAIGGYSRMALPSGGVGVGVYG----GPYP 158
            ..|......|.|:.  |:.......|:.   .|....:.|....:..|....:.|:.    ...|
Human    73 LKRDKDAIYGHPLF--PLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKP 135

  Fly   159 SNEQNPYPSIGVDNSAFYA---------------------------------PLSNPYGIKDTS- 189
            ....||    .:||....|                                 |:......:|.|
Human   136 LFSSNP----ELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSS 196

  Fly   190 ---------PSTEM-----SAW------TSASLQSTTGYYS-----------------YDPTLAA 217
                     .||.:     |:|      ||.....|.|..|                 .|.::|:
Human   197 KSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVAS 261

  Fly   218 YGYG----PNYDLAARRKNATRESTAT--LKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTW 276
            .|.|    |:.|...::|.......||  ::|||.:|..:|||::.:|..||..|.:|:.||:.|
Human   262 PGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNW 326

  Fly   277 FANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAE 341
            |.|||||:.:.   ..:..|:.     |.:.|....:.|         |:.|..|.:.|.:
Human   327 FINARRRIVQP---MIDQSNRA-----GFLLDPSVSQGA---------AYSPEGQPMGSFV---- 370

  Fly   342 KEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQH--- 403
                ..|.|.:.:  .|..|.:|.|  .|.:..|...|..|..||.....|   |||.|::|
Human   371 ----LDGQQHMGI--RPAGLQSMPG--DYVSQGGPMGMSMAQPSYTPPQMT---PHPTQLRHGPP 424

  Fly   404 -HQQQQQQQQNQQQLQHHQMDQPYYHPG 430
             |........:...:.|   ..|..|||
Human   425 MHSYLPSHPHHPAMMMH---GGPPTHPG 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	18/38 (47%)
		IRO	455..472	CDD:214716
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		17/125 (14%)
		Meis_PKNOX_N	110..194	CDD:406806	10/87 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		18/89 (20%)
		Homeobox_KN	294..333	CDD:399131	18/38 (47%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		15/33 (45%)
		PAT1	<335..>463	CDD:401645	32/150 (21%)
		Transcriptional activation domain	340..477		32/142 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900