DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and MEIS1

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_002389.1	Gene:	MEIS1 / 4211	HGNCID:	7000	Length:	390	Species:	Homo sapiens

Alignment Length:	175	Identity:	44/175 - (25%)
Similarity:	75/175 - (42%)	Gaps:	37/175 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TEMSAWT-----SASLQ-------STTGYYSY------------DPTLAAYGYG----PNYDLAA 228
            |:..:|.     :||.:       |:.|:.|:            |.::|:...|    |:.|...
Human   208 TDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKR 272

  Fly   229 RRKNATRESTAT--LKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKK 286
            .:|.......||  ::|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||     :.:
Human   273 HKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQ 337

  Fly   287 ENKMTWE--PKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPG 329
            .|:...:  |.|.......|.:.|.::.......|.:|....:.|
Human   338 SNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMG 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	18/38 (47%)
caup	NP_524046.2	IRO	455..472	CDD:214716
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:406806
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..279		13/70 (19%)
		Homeobox_KN	290..329	CDD:399131	18/38 (47%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:26550823, ECO:0000305\|PubMed:28473536	299..329		14/29 (48%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		8/48 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900