DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caup and irx3

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_001001216.1	Gene:	irx3 / 407888	XenbaseID:	XB-GENE-480486	Length:	448	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	164/534 - (30%)
Similarity:	226/534 - (42%)	Gaps:	148/534 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 YDPARLAIGGYSRMAL---PSG---GVGVGVYGGPY-------------PSNEQNP-YPSIGVDN 172
            |...|..:|| :|...   |:|   .|...|||.||             |.:.:.| :|.:|
Frog    15 YPSDRQNVGG-TRSGTELSPAGTLSNVLSSVYGTPYAAAAAAQAYGAFLPYSAELPIFPQLG--- 75

  Fly   173 SAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDLA--ARRKNATR 235
                    :.|.:|| ||..:.:|::             .|..|.|.|| .|...  :|.|||||
Frog    76 --------SQYEMKD-SPGVQHAAFS-------------HPHAAFYPYG-QYQFGDPSRPKNATR 117

  Fly   236 ESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTED 300
            |||:||||||:||:|||||||||||||||||||||||||||||||||||||||||||.|:::|::
Frog   118 ESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDE 182

  Fly   301 DDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDL--DREPHNLVA 363
            :.:...||.|::|.. |..::..|..|..:...|.:|...:.::.|  |.|.|.  |.|..:
Frog   183 EGNAYGSDHEEDKHE-DDEEIDLENIDTEDIESKEDLDDPDTDIHS--DSKTDARSDSEASD--- 241

  Fly   364 MRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHH-QMDQPYY 427
                       |...::|......:|          .:...|...::.|::..|... :..||
Frog   242 -----------GFEDLNAPEDRLLKS----------VVGQRQVLNEEPQDKCALSSDAKASQP-- 283

  Fly   428 HPGGYGQEESGEFAAQKNPLSRDCGIP-----VPAS-KPKIWSVADTAACKTPPPTAAYLG---- 482
                         |.::..|.|....|     :||: ||||||:|:||.....|..:...|
Frog   284 -------------ACEQIKLDRIPSSPPLENNIPAAHKPKIWSLAETATTPDNPRRSPNTGGSVN 335

  Fly   483 -QNFYPPSSADQQLPHQPLQQHQ--------QQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSM 538
             ||..    |..:|...|..:.|        .|||..|                :|......||
Frog   336 TQNLI----AQHRLIASPGSRFQGWTGRAFSAQQLSLL----------------NSAHFLQGLS- 379

  Fly   539 MSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSST----GKLPPTHIHPAPQRVGFPEIQPDTPP 599
            :|..|.||..:..|.|   |...|...|.:..|||    .|:|..:       ..|..:|..:..
Frog   380 VSHTALGSGTASFPKA---AEPKHSTDSLTDRSSTVDIEKKIPVLN-------TAFQPVQRRSQN 434

  Fly   600 QTPPTMKLNSSGGS 613
            |....|.|::...|
Frog   435 QLDAAMILSALSSS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	11/17 (65%)
irx3	NP_001001216.1	Homeobox_KN	126..165	CDD:310480	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..250		23/95 (24%)
		IRO	304..321	CDD:214716	11/16 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..410		6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020