DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and Irx6

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_001095883.1	Gene:	Irx6 / 307715	RGDID:	1564830	Length:	443	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	172/567 - (30%)
Similarity:	229/567 - (40%)	Gaps:	195/567 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PVGLSSAAQDLPSRGS---CCENGRPIITD----PVSGQTVCSCQYDPARLAIGGYSRMALPSGG 147
            |.|  .|:|.|.|..|   |||.....::|    ..|..|:|...||...|.      .|.|..|
  Rat     9 PYG--GASQFLVSASSSATCCETAPRSVSDVASASTSASTLCCAPYDSRLLG------SARPELG 65

  Fly   148 VGVGVYGGPYPSNEQNP-YPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSY 211
            ..:|:||.||.:.:..| |.:.|.:.......|:..|..||.:.|      .:.||.....||.|
  Rat    66 AALGIYGAPYAAAQSYPGYLTYGPEPPTLCGALNPQYEFKDAAGS------FTPSLTQPGAYYPY 124

  Fly   212 DPTLAAYGY----GPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQ 272
            :.||..|.|    |.....|.||||||||||:.|||||.||:|||||||||||||||||||||||
  Rat   125 ETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQ 189

  Fly   273 VSTWFANARRRLKKENKMTWEPKNKTEDD-------DD--GMMSDDEKEKDAGDGGKLSTEAFDP 328
            ||||||||||||||||||||.||||..::       :|  |.::.|.|:..|      |.||  .
  Rat   190 VSTWFANARRRLKKENKMTWVPKNKGGEERKADGGGEDALGCLNGDTKDATA------SQEA--Q 246

  Fly   329 GNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTH 393
            |.||  |:|...|:|.:.  :::.:.::|...:.|.|.|..:  |..|.|:.|..:
  Rat   247 GLQL--SDLEDLEEEEEE--EEEEEAEKEEAAVSAARRLVGF--PKSAQPLPAPCA--------- 296

  Fly   394 THPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPL-SRDCGIPVP- 456
                                                           |||:..| |.:||:.||
  Rat   297 -----------------------------------------------AAQEGCLESTECGLAVPR 314

  Fly   457 ------------------------------ASKPKIWSVADTAACKTPPPTAAYLGQNFYPP--- 488
                                          ..||:|||:|.|||      ::|..|....||
  Rat   315 FSFTEAPQSGEADFITAEPSGPTMIVHYPSGHKPRIWSLAHTAA------SSAVKGAPSTPPRGQ 373

  Fly   489 SSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGGSPYSRIPT 553
            |.....:|.||      ..:::|                          ::..::||...|
  Rat   374 SPECHMIPRQP------SSVRRL--------------------------LVPRFSGGEENS---- 402

  Fly   554 AYTEAMGMHLPSSSSSSSSTGKLP--PTHIHPAPQRVGFPEIQPDTP 598
                      |:..:..:||..|.  |.:..|.|:| ..||::...|
  Rat   403 ----------PAVKAFGNSTFALQGLPLNCAPCPRR-REPEVRFQYP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	11/47 (23%)
Irx6	NP_001095883.1	COG5576	<142..222	CDD:227863	65/79 (82%)
Irx6	NP_001095883.1	Homeobox_KN	161..200	CDD:283551	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8066
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3863
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm9040
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930