DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and Irx4

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_001100800.1	Gene:	Irx4 / 306655	RGDID:	1309309	Length:	515	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	181/573 - (31%)
Similarity:	241/573 - (42%)	Gaps:	155/573 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SSAAQDLPSRGS---CCENGRPIITD---PVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGV 152
            |||.|.|.:..|   |||:|...:.|   ..|.|....|....:||.  ..:|..|.| ...:||
  Rat    11 SSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLL--ATARHELNS-AAALGV 72

  Fly   153 YGGPYPSNE-QNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQST--TGYYSYDPT 214
            ||.||.|:: ...|.:.|.:.||||:  .|.:..||.:.|:.      |.|..|  ..||.|:||
  Rat    73 YGSPYSSSQGYGNYVTYGSEASAFYS--LNSFESKDGTGSSH------AGLPPTAAAAYYPYEPT 129

  Fly   215 LAAYGYG--PNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWF 277
            |..|.|.  ...|...||||||||:|:||||||.||:||||||||||||||||||||||||||||
  Rat   130 LGQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWF 194

  Fly   278 ANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSE--LGKA 340
            |||||||||||||||.|:||..|:.......:|:|  ||:     .|:.:...:.:|||  .||.
  Rat   195 ANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEE--AGE-----EESREEPLKSVKSEGPAGKE 252

  Fly   341 EKEVDSSGDQKLD-LDRE-----------PHNLVAMRGLAPYATPPGA---------HPMHAAYS 384
            :||::.|..:..| ||.|           |.:.|..| :.|.:..||.         .|:..|..
  Rat   253 DKELELSDLEDFDPLDTETSECELKTPFQPLDSVPER-IPPSSDGPGTGKEAPVTLRMPLGTADG 316

  Fly   385 SYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGE----FAAQKN 445
            :....                    ..:..:......:..|  ..|..|..::.|    ||....
  Rat   317 AVMDG--------------------DLERARNCLRSTVVAP--DSGAEGGPQACEAKLTFAPAGA 359

  Fly   446 PLSRDCGIPVPASKPKIWSVADTAACKTPPPTAAYLGQNFYP----------------PSSADQQ 494
            |       |...:||:|||:|.||..    ..|..|.|..:|                |:|:
  Rat   360 P-------PNLETKPRIWSLAHTATA----AAATALSQTEFPSCMLKRQGSTGASAVTPASS--- 410

  Fly   495 LPHQP-----LQQHQQQQLQQLQQQQQHHHHPHHHHPHHSMELGSPLSMMSSYAGG---SP---Y 548
             |..|     |.:||.                            ||::.:.::..|   .|   :
  Rat   411 -PAVPAASGTLDRHQD----------------------------SPVTSLRNWVDGVFHDPILRH 446

  Fly   549 SRIPTAYTEAMGMHL-PSSSSSSSSTGKLPPTHIHPAPQRVGF-PEIQPDTPP 599
            |.:..|:..|.|..| |.....:...|    |::...|....| |.:..|..|
  Rat   447 STLNQAWATAKGALLDPGPLGRNLGAG----TNVLTTPLACSFRPTVPQDVSP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	8/16 (50%)
Irx4	NP_001100800.1	Homeobox_KN	161..200	CDD:283551	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8066
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3863
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm9040
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930