DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment caup and Pknox2

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_001025009.1	Gene:	Pknox2 / 208076	MGIID:	2445415	Length:	474	Species:	Mus musculus

Alignment Length:	310	Identity:	72/310 - (23%)
Similarity:	116/310 - (37%)	Gaps:	77/310 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 GGPYPSNE-----------QN-PYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMS----AWTSASL 202
            ||||..|:           || |....||.|        ||.||  ..|::.:.    |.|:.:.
Mouse   181 GGPYSPNQPSINLHSQDLLQNSPNSMSGVSN--------NPQGI--VVPASALQQGNIAMTTVNS 235

  Fly   203 QSTTGYYSYDPTLAAYGYGP------------------NYDLAARRKNATRES-----------T 238
            |..:|...|.|.......|.                  |.||.:...|..::|           |
Mouse   236 QVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHAT 300

  Fly   239 ATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDD 303
            ..:::||.:|..:||||:.||..:|..|.:||.||:.||.|||||:       .:|.....:.|.
Mouse   301 NIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRI-------LQPMLDASNPDP 358

  Fly   304 GMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGLA 368
            ...:...|.:..      .|:.|.| |.:....|.:......::.|..::||    ||.::.  :
Mouse   359 APKAKKIKSQHR------PTQRFWP-NSIAAGVLQQQGGTPGTNPDGSINLD----NLQSLS--S 410

  Fly   369 PYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQ 418
            ..||......|.||:..  ....|.........:..:::::.::...:||
Mouse   411 DNATMAMQQAMMAAHDD--SLDGTEEEDEDDMEEEEEEEEELEEEADELQ 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	20/38 (53%)
caup	NP_524046.2	IRO	455..472	CDD:214716
Pknox2	NP_001025009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		gliding_GltG	5..>77	CDD:411344
		Meis_PKNOX_N	96..181	CDD:406806	72/310 (23%)
		Homeobox_KN	306..345	CDD:399131	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..371		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..405		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..474		5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900