Protein Alignment caup and IRX5

DIOPT Version :10

• Sequence 1: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Sequence 2: NP_005844.4
• Gene: IRX5 / 10265
• HGNCID: 14361
• Length: 483
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 170/602 - (28%)
• Similarity: 229/602 - (38%)
• Gaps: 214/602 - (35%)

  Fly   117 PVSGQTVCSC-QYDPARLAIGGYSRMALPSGGVGVGVYGG----PYPSNEQNPYPSIGVD----- 171
            |.:...:.|| .|..:.::......:...|.|.....|.|    ..||...|.:...|.|
Human    11 PSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAA 75

  Fly   172 NSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYG-PNYDLAARRKNATR 235
            .:||.:.:.:||   |.:|          .:..:.||:.|...|.:|.|| |.|     ||||||
Human    76 AAAFSSYVGSPY---DHTP----------GMAGSLGYHPYAAPLGSYPYGDPAY-----RKNATR 122

  Fly   236 ESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTED 300
            ::||||||||:||:|||||||||||||||||||||||||||||||||||||||||||.|:|::||
Human   123 DATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSED 187

  Fly   301 DDD----GMMSDDE----KEKDAGD------GGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQK 351
            :::    .:..:||    |.:|.||      ||.....|  .|.:.::.....|.||.:.|   .
Human   188 EEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAA--SGCERLQGPPTPAGKETEGS---L 247

  Fly   352 LDLD-REPHN---LVAMRGLAPYATPP---GAHPMHAAYSSYAQSHNTH-------THPHPQQMQ 402
            .|.| :||.:   |.|::|      ||   |..|...|.:..|:....|       ..|||...:
Human   248 SDSDFKEPPSEGRLDALQG------PPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGPHPAAGE 306

  Fly   403 HHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPA--SKPKIWSV 465
                                     .|.|.|    |.......|..     |.||  :|||:||:
Human   307 -------------------------VPPGPG----GPSVIHSPPPP-----PPPAVLAKPKLWSL 337

  Fly   466 ADTAACKTPPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHPHHSM 530
            |:.|                   :|:|:
Human   338 AEIA-------------------TSSDK------------------------------------- 346

  Fly   531 ELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSSTGKLPPTHIHPAPQRVGFPEIQP 595
                    :....||:..|..|.......|..|..|.:|             |||
Human   347 --------VKDGGGGNEGSPCPPCPGPIAGQALGGSRAS-------------PAP---------- 380

  Fly   596 DTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHSVTPVTVASMVNILYSNTDSGYGHGHSHGHGHGH 660
              .|...|:.:....||:..|....:::..:                   .||.:..|.||.|||
Human   381 --APSRSPSAQCPFPGGTVLSRPLYYTAPFY-------------------PGYTNYGSFGHLHGH 424

  Fly   661 -GHGLGHGHGLG-HGHG 675
             |.|.|...|.| |.:|
Human   425 PGPGPGPTTGPGSHFNG 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	245..283	CDD:428673	35/37 (95%)
		IRO	455..472	CDD:214716	9/18 (50%)
IRX5	NP_005844.4	Homeobox_KN	132..170	CDD:428673	35/37 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	177..392		68/348 (20%)
		IRO	327..344	CDD:214716	8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..442		9/19 (47%)