Protein Alignment ara and IRX1

DIOPT Version :9

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_077313.3
• Gene: IRX1 / 79192
• HGNCID: 14358
• Length: 480
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 176/628 - (28%)
• Similarity: 224/628 - (35%)
• Gaps: 229/628 - (36%)

  Fly    90 VGAGGGSSAGGGGPADLATGGSLDGNGVGTTPTAGGAGGGGSCCENGRPIMTDPVSGQTVCSCQY 154
            :.|.|..:.||..|..||...:.........|.|...|||.     |...:|.
Human    12 LSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGA-----GAAAVTS------------ 59

  Fly   155 DSARLALSSYSRLPAASVGVY-GTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGA 218
                 .|..|     |:.|.| |.|    :.:.:.....|.|.| |.:.:.|.|||
Human    60 -----VLGMY-----AAAGPYAGAP----NYSAFLPYAADLSLF-SQMGSQYELKD--------- 100

  Fly   219 WTSAGLQPTT-------GYYSYDPMSAYGGLLVSNSSYGASYDLAARRKNATRESTATLKAWLNE 276
              :.|:.|.|       .||.|.... ||.              ..|.||||||||:||||||||
Human   101 --NPGVHPATFAAHTAPAYYPYGQFQ-YGD--------------PGRPKNATRESTSTLKAWLNE 148

  Fly   277 HKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDD--- 338
            |:||||||||||||||||||||||||||||||||||||||||:||..::: |.:|.||...|
Human   149 HRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSK-DQEDGALFGSDTEG 212

  Fly   339 -----EKDKE------DLEPSKGSQGSVSLAKDETKEE-------EDAIDEDQ-KCLGQANILRA 384
                 |.|:|      |::......|..|...||.|.|       ..|:..|| ..|..|::|:
Human   213 DPEKAEDDEEIDLESIDIDKIDEHDGDQSNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLK- 276

  Fly   385 GFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPK 449
                |...      |.|....:..||.....   .|.....|.||.
Human   277 ----PQDS------PLGLAKEAPEPGSTRLL---SPGAAAGGLQGA------------------- 309

  Fly   450 NQLGRDCGVPIPATKPKIWSLADTV-------GCKTPPPAYMGH-------QSMPLQQQQQQQQQ 500
                       |..||||||||:|.       ....||||  ||       ...|||..
Human   310 -----------PHGKPKIWSLAETATSPDGAPKASPPPPA--GHPGAHGPSAGAPLQHP------ 355

  Fly   501 QQQAQHQYPPSEA------GR----------------DQQLFNGAAAPYLRPHTTAYGGFLGATT 543
                  .:.||..      |:                :.:.|.|..||:..||.
Human   356 ------AFLPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHG----------- 403

  Fly   544 QQLHTTNNSIPYSNMPPQQQQPQQQQQQLQQGGTIHTTGSS--SGPIIPLQFHNRHPQQQQQLQQ 606
                      |:...||..|.|.....     |.::...:|  |.|.:|          ::.|..
Human   404 ----------PHLPAPPPPQPPVAIAP-----GALNGDKASVRSSPTLP----------ERDLVP 443

  Fly   607 QSQSTASQRAMGFLEAQPDT--PPQTPPNMKVLSGALSLLPTA 647
            :..|.|.|....|...:.::  |.:..|.:      |:.||:|
Human   444 RPDSPAQQLKSPFQPVRDNSLAPQEGTPRI------LAALPSA 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
IRX1	NP_077313.3	Homeobox_KN	145..184	CDD:399131	37/38 (97%)
		HARE-HTH	<188..247	CDD:412843	17/59 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..268		21/78 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		26/114 (23%)
		IRO	<313..326	CDD:214716	9/12 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..480		22/120 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	0.375	Domainoid score	I8071
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.910