Protein Alignment ara and IRX3

DIOPT Version :10

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_005256196.1
• Gene: IRX3 / 79191
• HGNCID: 14360
• Length: 529
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 183/605 - (30%)
• Similarity: 221/605 - (36%)
• Gaps: 187/605 - (30%)

  Fly    91 GAGGGSSAGGGGPADLATGGS-LDGNGVGTTPTAGGAGGGGSCCENGRPIMTDPVSGQTVCSCQY 154
            ||.|||....|....|..|.| |:.:|                            |...|.|..|
Human    21 GAAGGSGGSAGARGGLGAGASELNASG----------------------------SLSNVLSSVY 57

  Fly   155 DSARLALSSYSRLPAASVGVYGTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAW 219
            .:...|.::     ||:...||...|...:.|          .:..|...|.|||: .|.:..|.
Human    58 GAPYAAAAA-----AAAAQGYGAFLPYAAELP----------IFPQLGAQYELKDS-PGVQHPAA 106

  Fly   220 TSAGLQPTTGYYSY------DPMSAYGGLLVSNSSYGASYDLAARRKNATRESTATLKAWLNEHK 278
            .:|...|...:|.|      ||                     :|.||||||||:|||||||||:
Human   107 AAAFPHPHPAFYPYGQYQFGDP---------------------SRPKNATRESTSTLKAWLNEHR 150

  Fly   279 KNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVS-----DD 338
            |||||||||||||||||||||||||||||||||||||||||||.|::|||::.:|..|     |:
Human   151 KNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDE 215

  Fly   339 EKDKED-----------LEPSKGSQGSVSLAKDETKEEEDAIDED----QKCLGQANILR----A 384
            |:|:||           |...:...|...||.|:..||.|..:.|    :..|..|...|    .
Human   216 EEDEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDL 280

  Fly   385 GFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPK 449
            |.|..|....|    ....||.|......|.....||..........||             .|.
Human   281 GLGPISDSKNS----DSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLP-------------SPP 328

  Fly   450 NQLGRDCGVPIPAT---KPKIWSLADTV----GCKTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQ 507
            ..|......|.||:   ||||||||:|.    ..:..||...|.
Human   329 VSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRSPPGAGGS--------------------- 372

  Fly   508 YPPSEAGRDQ--QLFNGAAAPYLRPHTTAYGGFLGATTQQLHTTNNSIPYSNMPPQQQQPQQQQQ 570
             ||..|....  ||...|||.......:|..|...|.|.:        |:...||
Human   373 -PPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNR--------PFPGPPP---------- 418

  Fly   571 QLQQGGTIH---TTGSSSGPIIPLQFHNRHPQQQQQLQQQSQSTASQRAMGFLEAQPDTPPQTPP 632
                |..:|   ..||:...::.|.....||               ..|..|  |:|..|.....
Human   419 ----GPRLHPLSLLGSAPPHLLGLPGAAGHP---------------AAAAAF--ARPAEPEGGTD 462

  Fly   633 NMKVLSGALSLLPTATQ-VP 651
            ....|.....||.||.| ||
Human   463 RCSALEVEKKLLKTAFQPVP 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	56/80 (70%)
		Homeobox_KN	274..312	CDD:428673	36/37 (97%)
IRX3	XP_005256196.1	Homeobox_KN	146..184	CDD:428673	36/37 (97%)
		IRO	344..359	CDD:214716	9/14 (64%)