Protein Alignment ara and IRX6

DIOPT Version :10

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_077311.2
• Gene: IRX6 / 79190
• HGNCID: 14675
• Length: 446
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 154/479 - (32%)
• Similarity: 211/479 - (44%)
• Gaps: 126/479 - (26%)

  Fly   118 GTTPTAGGAGGGGSCCENGRPIMTDPVSGQT----VCSCQYDSARLALSSYSRLPAASVGVYGTP 178
            |.:.....|....:|||:.:..::|..||.|    :|...||| ||..|:...|.|| :|:||.|
Human    12 GASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDS-RLLGSARPELGAA-LGIYGAP 74

  Fly   179 Y---PSTDQNP-YQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQP--------TTGYY 231
            |   .:....| |.....:..:.|..|:..|..|:..     |::||:..||        |.|.|
Human    75 YAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAA-----GSFTSSLAQPGAYYPYERTLGQY 134

  Fly   232 SYDPMSAYGGLLVSNSSYGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITK 296
            .|:   .||.:.:|.         |.||||||||:|:|||||||||:||||||||||||||||||
Human   135 QYE---RYGAVELSG---------AGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITK 187

  Fly   297 MTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEK------DKEDLEPSKGSQG-- 353
            |||||||||||||||||||||||||.|||:..::..|...:::.      |.:::..|:.::|
Human   188 MTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLR 252

  Fly   354 --SVSLAKDETKEEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYH 416
              .:...::|.:|||:|.||:.       :..||........|:...||             |..
Human   253 LSDLEDLEEEEEEEEEAEDEEV-------VATAGDRLTEFRKGAQSLPG-------------PCA 297

  Fly   417 HQHPAYYQAGQQGGMLPFHGENSK--------LQTDLGDPKNQLGRDCGVPIPATKPKIWSLADT 473
            .......:..:.|...|....|..        |..:.|.|:..:...|     ..||:|||||.|
Human   298 AAREGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPC-----LEKPRIWSLAHT 357

  Fly   474 V------------------GCK----TPP--------------------PAYMGH-----QSMPL 491
            .                  .|:    .||                    |...|:     |.:||
Human   358 ATASAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGLPL 422

  Fly   492 QQQQQQQQQQQQAQHQYPP-SEAG 514
            ......::.:...|.|||. :|||
Human   423 NCAPCPRRSEPVVQCQYPSGAEAG 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	60/80 (75%)
		Homeobox_KN	274..312	CDD:428673	36/37 (97%)
IRX6	NP_077311.2	COG5576	<145..223	CDD:227863	66/86 (77%)
		Homeobox_KN	165..203	CDD:428673	36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..273		18/64 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..394		3/31 (10%)