DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and Irx6

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_071873.2	Gene:	Irx6 / 64379	MGIID:	1927642	Length:	439	Species:	Mus musculus

Alignment Length:	479	Identity:	155/479 - (32%)
Similarity:	201/479 - (41%)	Gaps:	149/479 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 AGGGGSCCENG-RP---IMTDPVSGQTVCSCQYDSARLALSSYSRLPAASVGVYGTPYPSTDQNP 186
            |....:|||.. ||   :.:...|..|:|...||| ||..|:...|.|| :|:||.||.:....|
Mouse    20 ASSSATCCETAPRPVSDVASASTSASTLCCTPYDS-RLLGSARPELGAA-LGIYGAPYAAAQSYP 82

  Fly   187 -YQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAG----LQPTTGYYSYDPMSAYGGLLVSN 246
             |.:.|.:.......|:..|..|| .||....:.|..|    .:.|.|.|.||   .|||:.:|:
Mouse    83 GYLTYGPEPPTLCGALNPQYEFKD-AAGSFAPSLTQPGAYYPYETTLGQYQYD---RYGGVELSS 143

  Fly   247 SSYGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARR 311
                     |.||||||||||:.|||||:||:|||||||||||||||||||||||||||||||||
Mouse   144 ---------AGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARR 199

  Fly   312 RLKKENKMTWEPKN------RTDDDDDAL--VSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDA 368
            ||||||||||.|||      :.|..:|:|  ::.|.||....:.::|.:.|.....:|.:|||:|
Mouse   200 RLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKDATASQEARGLRLSDLEDLEEEEEEEEA 264

  Fly   369 IDE--------------------------DQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSG 407
            .:|                          .::||...   ..|.|.|..........|.....:.
Mouse   265 EEEAAVSAARRLADFQKSTQPLPAPCAAAQERCLESR---ECGLGLPRFSFTEAPQSGEADFITA 326

  Fly   408 HPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLAD 472
            .|||.....|     |.:|.                                    ||:|||||.
Mouse   327 EPGGPTMILH-----YPSGH------------------------------------KPRIWSLAH 350

  Fly   473 TVGC-------KTPPPAY----------------------------------MGH-----QSMPL 491
            |...       .|||.|.                                  .|:     |.:||
Mouse   351 TAAASAVESAPSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEGEEDSPAAKAFGNSTFTLQGLPL 415

  Fly   492 QQQQQQQQQQQQAQHQYPP-SEAG 514
            ......::::.:.:.|||. :|||
Mouse   416 NCAPYPRRREPEVRFQYPSGAEAG 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
Irx6	NP_071873.2	COG5576	<142..232	CDD:227863	68/98 (69%)
		Homeobox_KN	161..200	CDD:283551	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..270		22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9093
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8793
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860