DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and PKNOX2

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001369252.1	Gene:	PKNOX2 / 63876	HGNCID:	16714	Length:	472	Species:	Homo sapiens

Alignment Length:	289	Identity:	61/289 - (21%)
Similarity:	105/289 - (36%)	Gaps:	102/289 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 GVYGTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMG--AWTSAGLQPTTGYYSYDP 235
            |.|....||.:.:....:....::.....:||.|:....:..:.|  |.|:...|..:|...|.|
Human   182 GPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQP 246

  Fly   236 MS-------------AYGGLLVSNSSYGASYDLAARRKNATRES-----------TATLKAWLNE 276
            ::             ..|.:.:.|:.  .:.||.:...|..::|           |..:::||.:
Human   247 VTMVTSQGQVVTQAIPQGAIQIQNTQ--VNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQ 309

  Fly   277 HKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRL---------------KKENKMTWEPKNR 326
            |..:||||:.||..:|..|.:||.||:.||.|||||:               .|:.|....|..|
Human   310 HLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQR 374

  Fly   327 -------------------TDDD----------------------------DDALVSDDEKDKED 344
                               |:.|                            ||:|...:|:|:::
Human   375 FWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQAMMAAHDDSLDGTEEEDEDE 439

  Fly   345 LEPSKGSQGSVSLAKDETKEEEDAIDEDQ 373
            :|            ::|.:|.|:.:||.|
Human   440 ME------------EEEEEELEEEVDELQ 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	20/38 (53%)
PKNOX2	NP_001369252.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		gliding_GltG	5..>77	CDD:411344
		Meis_PKNOX_N	96..181	CDD:406806
		Homeobox_KN	306..345	CDD:399131	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..371		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..405		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..472		12/47 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810