Protein Alignment ara and TGIF2

DIOPT Version :10

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_068581.1
• Gene: TGIF2 / 60436
• HGNCID: 15764
• Length: 237
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 66/296 - (22%)
• Similarity: 97/296 - (32%)
• Gaps: 103/296 - (34%)

  Fly   244 VSNSSYGAS---YDLAARRK---NATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQV 302
            :|:|..|..   ..||.:||   |..:||...|:.||..|:.|.||::.||:.|:..|.:::.|:
Human     1 MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQI 65

  Fly   303 STWFANARRR-----LKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDET 362
            ..||.|||||     |:|:.|          |.:...:|.......|:...:||..|| ||....
Human    66 CNWFINARRRLLPDMLRKDGK----------DPNQFTISRRGGKASDVALPRGSSPSV-LAVSVP 119

  Fly   363 KEEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQ 427
                          ...|:|..........||.|..|.                    |.:..|:
Human   120 --------------APTNVLSLSVCSMPLHSGQGEKPA--------------------APFPRGE 150

  Fly   428 QGGMLPFHGENSKL----QTDLGDPKNQLGRDCGVPIPATKPKIWSLADTVGCKTPPPAYMGHQS 488
            .....|.....|.|    :.:.|.|...|                       ..||||.
Human   151 LESPKPLVTPGSTLTLLTRAEAGSPTGGL-----------------------FNTPPPT------ 186

  Fly   489 MPLQQQQQ-------------QQQQQQQAQHQYPPS 511
             |.:|.::             |:..:.:.|.|..||
Human   187 -PPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPS 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	31/84 (37%)
		Homeobox_KN	274..312	CDD:428673	15/37 (41%)
TGIF2	NP_068581.1	Homeobox_KN	37..75	CDD:428673	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..106		3/18 (17%)
		Repressive function	103..237		31/184 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..193		9/50 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..237		4/9 (44%)