DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and irx5a

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001038692.1	Gene:	irx5a / 573346	ZFINID:	ZDB-GENE-010716-2	Length:	446	Species:	Danio rerio

Alignment Length:	458	Identity:	146/458 - (31%)
Similarity:	193/458 - (42%)	Gaps:	135/458 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 YSRLPAASVGVYGTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGA--GPEMG--AWTSAGL 224
            |...|:||:.:|..|..||            |....|.:...|...:|:  .|..|  |:|||
Zfish     7 YLYQPSASLALYSCPAYST------------SVISGPRTEELGRSSSGSAFAPYAGSTAFTSA-- 57

  Fly   225 QPTTGYYSYDPMSAYGGLLVSNSSYGAS-------------------------YDLAARRKNATR 264
              :.||.|:.|.||......:.:||.:|                         |...|.||||||
Zfish    58 --SPGYNSHLPYSADAAAAATFTSYVSSPYDHTTGMAGSIGYHPYAAPLGSYPYGDPAYRKNATR 120

  Fly   265 ESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDD 329
            ::|||||||||||:|||||||||||||||||||||||||||||||||||||||||||.|:||::|
Zfish   121 DATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSED 185

  Fly   330 DDDALVSDDEKDKEDLEPSKGSQGSVSL------------------AKDETKEEE---DAIDEDQ 373
            :::....|.||:.:| ||:|.:....|.                  .||||..::   ...|.:.
Zfish   186 EEEDENIDLEKNDDD-EPNKPTDKGDSTDTEADHKLINPGEIPCDRFKDETHSKDLDPPLTDSEL 249

  Fly   374 KCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAG-----QQGGMLP 433
            |...:...|.|....|:..|                          |:..|.|     |:....|
Zfish   250 KEAEERTDLLAEQAKPTTSS--------------------------PSVLQRGSDLITQEKPSEP 288

  Fly   434 FHGE---NSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTV----GCKTPPPAYMGHQSMPL 491
            .|..   ||.:.:.:..|.:           |.|||:||||:..    .||....|   .|:..|
Zfish   289 GHAASTGNSNVTSVIHSPPS-----------APKPKLWSLAEIATSSDRCKGSSEA---SQAAGL 339

  Fly   492 QQQQ--QQQQQQQQAQHQYP-PSEAGRDQQLFNGAAAPYLRPHTTAYGGFLGATT----QQLHTT 549
            .|..  .......::..|.| |:.....:.::      |..|.   |.|:...:|    ...|.|
Zfish   340 SQSTVIASAASPTRSSPQCPLPNNTVLSRPIY------YTSPF---YPGYTNYSTFGHLHSSHGT 395

  Fly   550 NNS 552
            |.|
Zfish   396 NTS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
irx5a	NP_001038692.1	Homeobox_KN	129..168	CDD:283551	37/38 (97%)
irx5a	NP_001038692.1	IRO	307..324	CDD:214716	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8040
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.900