DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ara and Irx4

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_061373.1	Gene:	Irx4 / 50916	MGIID:	1355275	Length:	515	Species:	Mus musculus

Alignment Length:	535	Identity:	182/535 - (34%)
Similarity:	236/535 - (44%)	Gaps:	138/535 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SCCENGRPIMTD---PVSGQTVCSCQ-YDSARLALSSYSRLPAASVGVYGTPYPSTD-QNPYQSI 190
            :|||:|...:.|   ..|.|....|. |:|..||.:.:....||::||||:||.|:. ...|.:.
Mouse    25 TCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGSPYGSSQGYGNYVTY 89

  Fly   191 GVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPT--TGYYSYDP-MSAYGGLLVSNSSYGAS 252
            |.::|||||  .|.:..|| |.|.     :.|||.||  ..||.|:| :|.|     ....|| :
Mouse    90 GSEASAFYS--LNSFESKD-GTGS-----SHAGLPPTAAAAYYPYEPALSQY-----PYDRYG-T 140

  Fly   253 YDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 317
            .|...||||||||:|:||||||.||:|||||||||||||||||||||||||||||||||||||||
Mouse   141 VDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 205

  Fly   318 KMTWEPKNRTDDD-------DDALVSDDEKDKEDLEPSKGSQGSVSLAKDETK------EEEDAI 369
            ||||.|:|:..|:       ::....::|..:|.|:.:| |:|..  .||:.:      |:.|.:
Mouse   206 KMTWPPRNKCADEKRPYGEGEEEEAGEEESREEPLKSAK-SEGHA--GKDDKELELSDLEDFDPL 267

  Fly   370 D-EDQKCLGQANILRAGFGYPSAGSG------SGGYPGGGGSSS-------GHPGG--------- 411
            | |..:|     .|:..|  .|..||      |...||.|..:|       |..||
Mouse   268 DAETSEC-----ELKTPF--QSLDSGPERIPASSDGPGTGKEASTTLRMPLGTAGGAVMDGDLER 325

  Fly   412 ---------YHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPATKPKI 467
                     ..|         .:|.:||  |...|........|.|.|.          .|||:|
Mouse   326 ARNCLRSTVVVP---------DSGAEGG--PPACEAKLTFAQAGAPPNL----------ETKPRI 369

  Fly   468 WSLADTVGCKTP--------PPAYMGHQ-------SMPLQQQQQQQQQQQQAQHQYPPSEAGRD- 516
            ||||.|......        |...:..|       :.|..............:||..|..:.|:
Mouse   370 WSLAHTATAAAATALSQTEFPSCMLKRQGPTGVSATTPASSPAVTAPSGALDRHQDSPVTSLRNW 434

  Fly   517 -QQLFNGAAAPYLRPHT------TAYGGF---------LGATTQQLHTTNNSIPYSNMPPQQQQP 565
             ..:|:.   |.||..|      ||.|..         |||.|..| ||..:..:....||...|
Mouse   435 VDGVFHD---PILRHSTLNQAWATAKGALLDPGPLGRNLGAGTNVL-TTPLACSFPPTVPQDVPP 495

  Fly   566 QQQQQQL----QQGG 576
            ....::|    :.||
Mouse   496 AGASRELLATPKAGG 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
Irx4	NP_061373.1	Homeobox_KN	161..200	CDD:368670	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..258		16/55 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..307		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..425		2/26 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9093
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8793
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.910