Protein Alignment ara and IRX4

DIOPT Version :10

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001265562.1
• Gene: IRX4 / 50805
• HGNCID: 6129
• Length: 545
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 181/599 - (30%)
• Similarity: 242/599 - (40%)
• Gaps: 153/599 - (25%)

  Fly   131 SCCENGRPIMTD---PVSGQTVCSCQ-YDSARLALSSYSRLPAASVGVYGTPY-PSTDQNPYQSI 190
            :|||:|...:.|   ..|.|....|. |:|..||.:.:....||::||||.|| .|.....|.:.
Human    25 TCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGGPYGGSQGYGNYVTY 89

  Fly   191 GVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAG-----LQPTTGYYSYDPMSAYG-------GLL 243
            |.::|||||  .|.:..|| |:|...|....|.     .:|..|.|.||.:...|       ||.
Human    90 GSEASAFYS--LNSFDSKD-GSGSAHGGLAPAAAAYYPYEPALGQYPYDRIKRLGGHPHKGIGLD 151

  Fly   244 VS------NSSYGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQV 302
            :|      .|.|| :.|...||||||||:|:||||||.||:||||||||||||||||||||||||
Human   152 LSGLGRSPGSLYG-TMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQV 215

  Fly   303 STWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEKD--KEDL--EPSKGSQGSVSLAKDETK 363
            |||||||||||||||||||.|:|:..|:.......:|::  :|:.  ||.|.|:.:..:.|:|.:
Human   216 STWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKE 280

  Fly   364 EEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQ 428
            .|...:|:......:.........:.|...|....|..       |.|  |......|...:...
Human   281 LELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAA-------PDG--PVKEASGALRMSLAA 336

  Fly   429 GGMLPFHGE----NSKLQTDLGDPKNQLGRDCG----------VPIPAT-----KPKIWSLADTV 474
            ||......:    .|.|::....|:...|.:.|          ||..|:     ||:|||||.|.
Human   337 GGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTA 401

  Fly   475 GCKTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQYPPSEAGRDQQLFNGAAAPYLRPHTTAYGGFL 539
            .........:.....|....::|                        |.|||
Human   402 TAAAAAATSLSQTEFPSCMLKRQ------------------------GPAAP------------- 429

  Fly   540 GATTQQLHTTNNSI--PYSNMPPQQQQPQQQQQQLQQGGTIHTTGSSSGPIIPLQ------FHNR 596
             |.......|:.|:  |:|....:.|                     ..|:..|:      ||:
Human   430 -AAVSSAPATSPSVALPHSGALDRHQ---------------------DSPVTSLRNWVDGVFHD- 471

  Fly   597 HPQQQQQLQQQSQSTAS---------QRAMG---------FLEAQPDTPPQTPPNMKVLSGA--- 640
             |..:.....|:.:||.         .|::|         ...|.|...||..|    .:||
Human   472 -PILRHSTLNQAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAP----AAGAARE 531

  Fly   641 LSLLPTATQVPMTA 654
            |..||.|...|..|
Human   532 LLALPKAGGKPFCA 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	63/93 (68%)
		Homeobox_KN	274..312	CDD:428673	35/37 (95%)
IRX4	NP_001265562.1	Homeobox_KN	187..225	CDD:428673	35/37 (95%)