DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and Irx5

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001025215.1	Gene:	Irx5 / 498918	RGDID:	1565518	Length:	484	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	154/460 - (33%)
Similarity:	198/460 - (43%)	Gaps:	132/460 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 YSRLPAASVGVYGTPY--------PSTDQ----------NPYQSIGVDSSAFYSPLSNPYGLKDT 210
            |...|:||:.:|..|.        |.||:          :||    ..|:||.:|..........
  Rat     7 YLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPY----AGSTAFTAPSPGYNSHLQY 67

  Fly   211 GAGPEMGAWT-----------SAGLQPTTGYYSY-DPMSAYGGLLVSNSSYGASYDLAARRKNAT 263
            ||.|...|..           :.|:..:.||:.| .|:.:|            .|...|.|||||
  Rat    68 GADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYAAPLGSY------------PYGDPAYRKNAT 120

  Fly   264 RESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTD 328
            |::|||||||||||:||||||||||||||||||||||||||||.||||||||||||||.|:||::
  Rat   121 RDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKENKMTWTPRNRSE 185

  Fly   329 DDDDA----LVSDDE------KDKEDLE-PSKGS------------QGSVSLAKDETKEEEDAID 370
            |:::.    |..:||      :||.||| |..|.            ||.:|.|..||  |....|
  Rat   186 DEEEEENIDLEKNDEDEPQKPEDKGDLEGPEAGGTEQKAAAGCERLQGPLSPAGKET--EGSLSD 248

  Fly   371 EDQK---CLGQANIL----RAGFGYPS-------AGSGSGGYPGGGGSSSGHPGGYHPYHHQHPA 421
            .|.|   ..|:.:.|    |||...|:       |......||.|..:...||..
  Rat   249 SDFKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAPGPHPSA---------- 303

  Fly   422 YYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPA--TKPKIWSLAD------------ 472
                   |.:.|..|.:|.:.:....|.         |.||  .|||:||||:
  Rat   304 -------GELPPGSGGSSVIHSPPPPPP---------PPPAVLAKPKLWSLAEIATSSDKVKDGG 352

  Fly   473 --TVGCKTPP-PAYMGHQSMPLQQQQQQQQQQQQAQHQYP-PSEAGRDQQLFNGAAAPYLRPHTT 533
              :.|...|| |..:|.|::...:........:....|.| |......:.|:  ..||:. |..|
  Rat   353 GGSEGSPCPPCPGPIGGQTLGGSRASPAPAPARSPSAQCPFPGGTVLSRPLY--YTAPFY-PGYT 414

  Fly   534 AYGGF 538
            .||.|
  Rat   415 NYGSF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
Irx5	NP_001025215.1	Homeobox_KN	130..169	CDD:283551	36/38 (95%)
Irx5	NP_001025215.1	IRO	328..345	CDD:214716	8/16 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7886
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870