DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and irx4b

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001018329.2	Gene:	irx4b / 474318	ZFINID:	ZDB-GENE-040712-4	Length:	439	Species:	Danio rerio

Alignment Length:	501	Identity:	155/501 - (30%)
Similarity:	205/501 - (40%)	Gaps:	187/501 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AYTQFGYGGFPSASQLLPPSVQTTEDASANVNVNVNEALVMTNAPAMSPTGGQDCQGSQPSGGAG 67
            ::||||| .:|:|.|||
Zfish     2 SFTQFGY-SYPAAPQLL------------------------------------------------ 17

  Fly    68 GDASSGALSPNALSQNSNAATVVGAGGGSSAGGGGPADLATGGSLDGNGVGTTPTAGGAGGGGSC 132
                   :|.||||                      ....:.|||..:||.|:|
Zfish    18 -------MSSNALS----------------------TCFESSGSLLDSGVPTSP----------- 42

  Fly   133 CENGRPIMTDPVSGQTVCSCQ-YDSARLALSSYSRLPAASVGVYGTPYPSTDQN-PYQS---IGV 192
                          |....|. |:|..:|.|.:..:|.|   |||.   |..:| .|.|   .|.
Zfish    43 --------------QNSLYCPVYESRLVASSRHELIPTA---VYGN---SCSKNHVYDSCSTYGP 87

  Fly   193 DSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYD-PMSAYGGLLVSNSSYG-ASYDL 255
            ||:|.|     |.|..:...|.:.|   .:.:..::.||.|| |:..|     |...|| .|.|:
Zfish    88 DSAACY-----PLGKLNEKDGVQTG---HSRVTQSSAYYPYDYPIGQY-----SYDRYGYGSVDV 139

  Fly   256 AARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 320
            ..||||||||:|:||||||.|||||||||||||||||||||||||||||||||||||||||||||
Zfish   140 GTRRKNATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 204

  Fly   321 WEPKNRTDDDDDALVSDDEKDKEDL--EPSKGSQG-SVSLAKDETK------EEEDAIDEDQKCL 376
            |.|:|:..|:.:.  .||::|.::.  ||.|..|. :.:..||:|.      ::.|.::.|
Zfish   205 WSPRNKNSDEKEC--DDDQEDLDEAQEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESD---- 263

  Fly   377 GQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPG---------GYHPYHHQHPAYYQAGQQ--GG 430
                                     |......|.         ..||..|...|::::..:  .|
Zfish   264 -------------------------GSECESKPSFVVHVHSETSDHPETHFKDAFHESVTELTRG 303

  Fly   431 MLPFHGENSKLQTDLGDPKNQLGR---DCGVPIPATKPKIWSLADT 473
            :..|  ...:|:....|  :|:.:   ..|.....|||||||||.|
Zfish   304 VHKF--SEDRLRAPAED--HQMAKFYLQQGQKTIETKPKIWSLAQT 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
irx4b	NP_001018329.2	Homeobox_KN	157..196	CDD:283551	37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9005
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134285
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm6453
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.910