Protein Alignment ara and MEIS2

DIOPT Version :9

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 91/383 - (23%)
• Similarity: 135/383 - (35%)
• Gaps: 101/383 - (26%)

  Fly   131 SCCENGRPIMTDPVSGQTVCSCQYDSARLALSSYSRL-----------PAASVGVYGTPYPSTDQ 184
            ||.:...||  |.|..:...|.:.|...|:.||.:..           .|.|....|||.||:..
Human   177 SCLKGKMPI--DLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGG 239

  Fly   185 NPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSY 249
            :..|| |.:||      ....||.::.|.|..|.             ..||
Human   240 HASQS-GDNSS------EQGDGLDNSVASPGTGD-------------DDDP-------------- 270

  Fly   250 GASYDLAARRKNATRESTAT--LKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 312
              ..|...::|.......||  ::|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||
Human   271 --DKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRR 333

  Fly   313 LKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDAIDEDQKCLG 377
            :.:                 .::....:....|:||. |||:.  ...|.:.....:.:.|:.:|
Human   334 IVQ-----------------PMIDQSNRAGFLLDPSV-SQGAA--YSPEGQPMGSFVLDGQQHMG 378

  Fly   378 QANILRAGF-----GYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAG-QQGGMLPFHG 436
               |..||.     .|.|.|       |..|.|...|....|....||...:.| .....||.|.
Human   379 ---IRPAGLQSMPGDYVSQG-------GPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHP 433

  Fly   437 ENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTVGCKTPPPAYMGHQSMPLQQQ 494
            .:..:....|.|.:.     |:.:.|..|.:.:..|         ..:|.|.|.:..|
Human   434 HHPAMMMHGGPPTHP-----GMTMSAQSPTMLNSVD---------PNVGGQVMDIHAQ 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	18/38 (47%)
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		6/15 (40%)
		Meis_PKNOX_N	110..194	CDD:406806	6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		26/125 (21%)
		Homeobox_KN	294..333	CDD:399131	18/38 (47%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		15/33 (45%)
		PAT1	<335..>463	CDD:401645	31/162 (19%)
		Transcriptional activation domain	340..477		35/163 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810