DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and MEIS1

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_002389.1	Gene:	MEIS1 / 4211	HGNCID:	7000	Length:	390	Species:	Homo sapiens

Alignment Length:	225	Identity:	53/225 - (23%)
Similarity:	78/225 - (34%)	Gaps:	90/225 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 GPEMGAWTSAGLQPTTGYYSYDPMSAYGGLL---VSNSSYGASYDLAARRKNATRE------STA 268
            ||..|..||         :|.|..|..|..|   |::.|.|...|....:|...:.      :|.
Human   230 GPSSGGHTS---------HSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATN 285

  Fly   269 TLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDA 333
            .::|||.:|..:|||::.:|..||..|.:|:.||:.||.|||||:
Human   286 IMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI-------------------- 330

  Fly   334 LVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGY 398
                       ::|                    .||:..:.:.|      |..|...|...||:
Human   331 -----------VQP--------------------MIDQSNRAVSQ------GTPYNPDGQPMGGF 358

  Fly   399 ------------PG---GGGSSSGHPGGYH 413
                        ||   |.|.:.|..|.:|
Human   359 VMDGQQHMGIRAPGPMSGMGMNMGMEGQWH 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	18/38 (47%)
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:406806
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..279		15/57 (26%)
		Homeobox_KN	290..329	CDD:399131	18/38 (47%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:26550823, ECO:0000305\|PubMed:28473536	299..329		14/29 (48%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810