Protein Alignment ara and Irx1

DIOPT Version :10

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001100801.1
• Gene: Irx1 / 306659
• RGDID: 1309060
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 653
• Identity: 177/653 - (27%)
• Similarity: 225/653 - (34%)
• Gaps: 264/653 - (40%)

  Fly    66 AGGDASSGALSPNALSQNSNAATVVGAGGGSSAGGGGPADLATGGSLDGNGVGTTPTAGGAGGGG 130
            |.|..:.|...|..|      |....|...:|:|..|.|:|                  |||.|.
  Rat    14 AAGPGAYGGERPGML------AAAAAAAAAASSGRPGTAEL------------------GAGAGA 54

  Fly   131 SCCENGRPIMTDPVSGQTVCSCQYDSARLALSSYSRLPAASVGVYGTPYPSTDQNPYQSIGVDSS 195
            :                            |::|...:.||:....|.|    :.:.:.....|.|
  Rat    55 A----------------------------AVTSVLGMYAAAGPYAGAP----NYSAFLPYAADLS 87

  Fly   196 AFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTT-------GYYSYDPMSAYGGLLVSNSSYGASY 253
            .| |.:.:.|.|||           :.|:.|.|       .||.|.... ||.
  Rat    88 LF-SQMGSQYELKD-----------NPGVHPATFAAHTTPAYYPYGQFQ-YGD------------ 127

  Fly   254 DLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 318
              ..|.||||||||:|||||||||:||||||||||||||||||||||||||||||||||||||||
  Rat   128 --PGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 190

  Fly   319 MTWEPKNRTDDDDDALVSDD--------EKDKE-DLEPSKGSQGSVSLAKDETKEEEDAIDEDQK 374
            :||..::: |.:|.||...|        |.|:| |||.....|..........::|||.::..:.
  Rat   191 VTWGARSK-DQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERDGDQSNEDEEDKVEAPRA 254

  Fly   375 CLG-------QANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGML 432
            .:.       |::.|.|.....|..|     |.|.......||.....   .|.....|.||.
  Rat   255 RVAPPAPARDQSSPLSAAETLKSQDS-----PLGLAKEVSEPGSTRLL---SPGAAAVGLQGA-- 309

  Fly   433 PFHGENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTV-----GCKTPPPAYMGHQS---- 488
                                        |.:||||||||:|.     ..|..||....|.|
  Rat   310 ----------------------------PHSKPKIWSLAETATSPDGAPKASPPPPSSHASAHGP 346

  Fly   489 ---MPLQQQQQQQQQQQQAQHQYPPSEA------GR----------------DQQLFNGAAAPYL 528
               .|||..            .:.||..      |:                :.:.|.|.:||:.
  Rat   347 PSGSPLQHP------------AFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFLGVSAPHA 399

  Fly   529 RPHTTAYGGFLGATTQQLHTTNNSIPYSNMPPQQQQPQQQQQQLQQGGTIH--TTGSSSGPIIPL 591
            .||.                     |:...||..|.|.|...     |.:|  ...:||.|.:|
  Rat   400 APHG---------------------PHVTAPPPPQLPVQVAT-----GVLHGEKASASSSPALP- 437

  Fly   592 QFHNRHPQQQQQLQQQSQSTASQRAMGFLEAQPDTPPQ-------------------TPPNMKVL 637
                                  :|.   |..:||:|||                   ||..:..|
  Rat   438 ----------------------ERD---LVTRPDSPPQQLKSPFQPVRDNSLAPQEGTPRILAAL 477

  Fly   638 SGA 640
            |.|
  Rat   478 SSA 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	COG5576	<237..>318	CDD:227863	58/80 (73%)
		Homeobox_KN	274..312	CDD:428673	36/37 (97%)
Irx1	NP_001100801.1	Homeobox_KN	146..184	CDD:428673	36/37 (97%)
		DNA_pol_phi	<195..257	CDD:461488	15/62 (24%)
		IRO	309..326	CDD:214716	10/46 (22%)