DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and Irx4

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001100800.1	Gene:	Irx4 / 306655	RGDID:	1309309	Length:	515	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	179/531 - (33%)
Similarity:	231/531 - (43%)	Gaps:	142/531 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SCCENGRPIMTD---PVSGQTVCSCQ-YDSARLALSSYSRLPAASVGVYGTPYPSTD-QNPYQSI 190
            :|||:|...:.|   ..|.|....|. |:|..||.:.:....||::||||:||.|:. ...|.:.
  Rat    25 TCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGSPYSSSQGYGNYVTY 89

  Fly   191 GVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPT--TGYYSYDP-MSAYGGLLVSNSSYGAS 252
            |.::|||||  .|.:..|| |.|.     :.|||.||  ..||.|:| :..|     ....|| :
  Rat    90 GSEASAFYS--LNSFESKD-GTGS-----SHAGLPPTAAAAYYPYEPTLGQY-----PYDRYG-T 140

  Fly   253 YDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 317
            .|...||||||||:|:||||||.||:|||||||||||||||||||||||||||||||||||||||
  Rat   141 VDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 205

  Fly   318 KMTWEPKNRTDDD-------DDALVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEE-------DA 368
            ||||.|:|:..|:       ::....::|..:|.|:..| |:|.   |..|.||.|       |.
  Rat   206 KMTWPPRNKCADEKRPYGEGEEEEAGEEESREEPLKSVK-SEGP---AGKEDKELELSDLEDFDP 266

  Fly   369 ID-EDQKCLGQANILRAGF----GYPSAGSGSGGYPGGG-----------GSSSG---------- 407
            :| |..:|     .|:..|    ..|.....|...||.|           |::.|
  Rat   267 LDTETSEC-----ELKTPFQPLDSVPERIPPSSDGPGTGKEAPVTLRMPLGTADGAVMDGDLERA 326

  Fly   408 ---------HPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPAT 463
                     .|              .:|.:||  |...|........|.|.|.          .|
  Rat   327 RNCLRSTVVAP--------------DSGAEGG--PQACEAKLTFAPAGAPPNL----------ET 365

  Fly   464 KPKIWSLADTVGC-------KTPPPAYM-------GHQSM-PLQQQQQQQQQQQQAQHQYPPSEA 513
            ||:|||||.|...       :|..|:.|       |..:: |..............:||..|..:
  Rat   366 KPRIWSLAHTATAAAATALSQTEFPSCMLKRQGSTGASAVTPASSPAVPAASGTLDRHQDSPVTS 430

  Fly   514 GRD--QQLFNGAAAPYLRPHT------TAYGGF---------LGATTQQLHTTNNSIPYSNMPPQ 561
            .|:  ..:|:.   |.||..|      ||.|..         |||.|..| ||..:..:....||
  Rat   431 LRNWVDGVFHD---PILRHSTLNQAWATAKGALLDPGPLGRNLGAGTNVL-TTPLACSFRPTVPQ 491

  Fly   562 QQQPQQQQQQL 572
            ...|....::|
  Rat   492 DVSPAGASREL 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
Irx4	NP_001100800.1	Homeobox_KN	161..200	CDD:283551	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9101
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3863
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm9040
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930