DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ara and irx3a

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001307054.1	Gene:	irx3a / 30520	ZFINID:	ZDB-GENE-991119-5	Length:	454	Species:	Danio rerio

Alignment Length:	567	Identity:	168/567 - (29%)
Similarity:	228/567 - (40%)	Gaps:	180/567 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 RPIMTDPVSGQTVCSCQYDSARLA--LSSYSRLPAASVGVYGTPYPSTDQN----PYQSIGVDSS 195
            |||.:....|       ..|||..  ||....|......:||:|:.:....    ||.:   |.|
Zfish    12 RPIYSQDRQG-------IGSARAGTDLSPSGALSNVLSTMYGSPFAAAQSYGAFLPYSN---DLS 66

  Fly   196 AFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSYGASYDLAARRK 260
            .| :.|...|.|||           |.|:|.....:.:.....||.....:.|         |.|
Zfish    67 IF-NQLGAQYELKD-----------SPGVQHPGFAHHHPAFYPYGQYQFGDPS---------RPK 110

  Fly   261 NATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKN 325
            |||||||:||||||:||:|||||||||||||||||||||||||||||||||||||||||||.|::
Zfish   111 NATRESTSTLKAWLSEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRS 175

  Fly   326 RTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDETK--------EEEDAIDEDQKCLGQANIL 382
            |||::.:...||.|.|..|   .:..:..:.|...:|:        :|:|.:..|.|..|:
Zfish   176 RTDEEGNVYNSDHEGDDGD---KREDEEEIDLENIDTENIENKDDLDEQDELHSDLKLDGR---- 233

  Fly   383 RAGFGYPSAGSGSGGYPG--------------GG----GSSSGHPGGYHPYHHQHPAYYQAGQQG 429
                   |....|.||..              .|    |..:.|   :|.:.|.|..::.:.:|.
Zfish   234 -------SDSEISDGYEDLQGPEQRLFKAMVKDGKEIHGDRAEH---FHHHSHHHHLHHNSLEQA 288

  Fly   430 GMLPFHGENSKL-QTDLGDPKNQLGRDCGVPIPATKPKIWSLADTVGCKTPPPAYMGHQSMPLQQ 493
                 :||..|: |..:..|.::     ..|.||.||||||||:|......|
Zfish   289 -----NGEPVKINQAIINSPPSE-----NNPPPAPKPKIWSLAETATTPDNP------------- 330

  Fly   494 QQQQQQQQQQAQHQYPPSEAGRDQQLFNGAAAPYLRPHTTAYGGFLGATTQQLHTTNN--SIPYS 556
                                 |...|.||.:|              .:.||.:.|.:.  |.|..
Zfish   331 ---------------------RKSPLMNGTSA--------------ASATQTIITPHRLLSCPVG 360

  Fly   557 NMPPQQQQPQQQQQQLQQGGTIH--------------TTGSSSGPIIPLQFHNRHPQQQQQLQQQ 607
            .:          |....:|.|.|              ...|::|    |..::|   |.:...|.
Zfish   361 KI----------QSWTNRGFTAHQLALLNSNHYLGLSNQASANG----LALYSR---QAEDRSQN 408

  Fly   608 SQSTASQRAMGFLEAQPDT------PPQ-TPPNMKVLSGALSLLPTA 647
            |:||.::|:.. |||:...      |.| .|.|....:..||.|.::
Zfish   409 SESTVTERSSA-LEAEKKLLKTAFHPVQRRPQNQLEAAMVLSALSSS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
irx3a	NP_001307054.1	COG5576	<103..>191	CDD:227863	68/96 (71%)
irx3a	NP_001307054.1	Homeobox_KN	123..162	CDD:283551	36/38 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4341
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6453
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.100