DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and Mkx

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_808263.2	Gene:	Mkx / 210719	MGIID:	2687286	Length:	354	Species:	Mus musculus

Alignment Length:	272	Identity:	66/272 - (24%)
Similarity:	102/272 - (37%)	Gaps:	96/272 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSYGASYD--LA 256
            |..|...|.||:      .|||:|......|:              ..|.:.:...||..:  ..
Mouse    27 SRTFSGFLDNPH------TGPEVGIPDGPPLK--------------DNLSLRHRRTGARQNGGKV 71

  Fly   257 ARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK---KENK 318
            ..::.|.::....||.||.:|:.||||||.|||:||:.::|||.|||.||||||||||   ::..
Mouse    72 RHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPD 136

  Fly   319 MTWEPKNRTDDDDDALVSDDEKDKEDLEPSKGSQGSVSLAKDETKEEEDAIDEDQKCLGQANILR 383
            ::|..:.:.                   .:|..||:.         |..::..|
Mouse   137 LSWALRIKL-------------------YNKYVQGNA---------ERLSVSSD----------- 162

  Fly   384 AGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGMLPFH-----GENSKLQT 443
                               |.|....|...|.:|.:       ::|...|.|     ||:|.::.
Mouse   163 -------------------GDSCSEDGENPPRNHMN-------EEGYSTPAHHTVIKGESSAIKA 201

  Fly   444 DLGDPKNQLGRD 455
            . |.|:::...|
Mouse   202 G-GRPESRAAED 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	26/38 (68%)
Mkx	NP_808263.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..50		9/28 (32%)
		Homeobox_KN	88..127	CDD:368670	26/38 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..183		6/62 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..302
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810