Protein Alignment ara and Irx2

DIOPT Version :9

• Sequence 1: NP_524045.2
• Gene: ara / 39439
• FlyBaseID: FBgn0015904
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_034704.1
• Gene: Irx2 / 16372
• MGIID: 1197526
• Length: 474
• Species: Mus musculus
• Alignment Length: 540
• Identity: 163/540 - (30%)
• Similarity: 209/540 - (38%)
• Gaps: 201/540 - (37%)

  Fly   151 SC-QYDSARLALSSYSRLPAASVGVYGTPYPS----TDQ------NPYQSIGVDSSA-----FYS 199
            || .|.::.||......|..::.|...:|||.    |.|      :|.| ...|::|     |.|
Mouse    19 SCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAATGFGSPLQ-YSADAAAAAAAGFPS 82

  Fly   200 PLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYDPMSAYGGLLVSNSSYGASYDLAARRKNATR 264
            .:.:||....||               .||..||.|   ||     :::|....:..|.||||||
Mouse    83 YVGSPYDTHTTG---------------MTGAISYHP---YG-----SAAYPYQLNDPAYRKNATR 124

  Fly   265 ESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDD 329
            ::|||||||||||:|||||||||||||||||||||||||||||||||||||||||||.|:|:::|
Mouse   125 DATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRNKSED 189

  Fly   330 DD----DALVSDDE---KDKEDLEPSKGSQG--------------------------------SV 355
            :|    ||..|.:|   |.::..|.|...:|                                |.
Mouse   190 EDEDEGDASRSKEESSDKAQDGTETSAEDEGISLHVDSLTDHSCSAESDGEKLPCRAGDALCESG 254

  Fly   356 SLAKDETKEEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHP 420
            |..||:.::.||..||:.:|  :.::.                |....:||...|...|.....|
Mouse   255 SECKDKFEDLEDEEDEEDEC--ERDLA----------------PPKPVTSSPLTGVEAPLLSPAP 301

  Fly   421 AYYQAGQQGGMLPFHGENSKLQTDLGDPKNQLGRDCGVPIPATKPKIWSLADTV----------- 474
            .....|..||..|.....|.                |.|.||:|||:||||:..
Mouse   302 EAAPRGGSGGKTPLGSRTSP----------------GAPPPASKPKLWSLAEIATSDLKQPSLGP 350

  Fly   475 GCKTP-------------PPAYMGHQSMPLQQQQQQQQQQQQAQHQYPPSEAGRDQQLFNGAAAP 526
            ||..|             ||....:.:.||           ..:|.|..|              |
Mouse   351 GCGPPGLPAAAAPASTGAPPGGSPYSASPL-----------LGRHLYYTS--------------P 390

  Fly   527 YLRPHTTAYGGFLGATTQQ---LHTTNNSIPYSNMPPQQQQPQQQQQQLQQGGTIHT-------- 580
            :...:|. ||....|...|   .:.|..|.|                    |.|:|.
Mouse   391 FYGNYTN-YGNLNAALQGQGLLRYNTAASSP--------------------GETLHAMPKAASDT 434

  Fly   581 --TGSSSGPIIPLQFHNRHP 598
              .||.|     |:.|.|.|
Mouse   435 GKAGSHS-----LESHYRPP 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
Irx2	NP_034704.1	COG5576	<115..217	CDD:227863	72/101 (71%)
		Homeobox_KN	133..172	CDD:368670	37/38 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	177..220		16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..373		32/144 (22%)
		IRO	325..342	CDD:214716	9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..461		11/55 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	0.375	Domainoid score	I8067
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3968
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.920