DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ara and irx1

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001188351.1	Gene:	irx1 / 100038208	XenbaseID:	XB-GENE-486817	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	568	Identity:	173/568 - (30%)
Similarity:	221/568 - (38%)	Gaps:	202/568 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VGAGGGSSAGGGGPADLATGGSLDGNGVGTTPTAGGAGGGGSCCENGRPIMTDPVSGQTVCSCQY 154
            :.||..:..||..|..||...:          .|..|...||    |||...|
Frog    12 LSAGQAAVYGGERPGVLAAAAA----------AAAAAAAAGS----GRPTGAD------------ 50

  Fly   155 DSARLALSSYSRLPAASV-GVYGTPYPSTDQNPYQSIGVDSSAFYSPLSNPYGLKDTGAGPEMGA 218
                  |.|.|.....|| |:|.:||.:.:.:.:.....|.:.| |.:.:.|.|||
Frog    51 ------LGSSSTAAVTSVLGMYASPYSAPNYSAFLPYTTDLTLF-SQMGSQYELKD--------- 99

  Fly   219 WTSAGLQPTT-------GYYSYDPMSAYGGLLVSNSSYGASYDLAARRKNATRESTATLKAWLNE 276
              :.|:.|.|       |||.|.... ||.              ..|.||||||||:||||||||
Frog   100 --NPGVHPATFAAHTTPGYYPYGQFQ-YGD--------------PGRPKNATRESTSTLKAWLNE 147

  Fly   277 HKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEKD 341
            |:||||||||||||||||||||||||||||||||||||||||:||..  |:.:||:...||.|.|
Frog   148 HRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGA--RSKEDDNIFGSDTEGD 210

  Fly   342 KE--------DLEPSKGSQGSVSLAK-DETKEEEDAIDEDQKC--LGQAN----------ILRAG 385
            .|        |||       |:.:.| |:...|:...:||:|.  |.|..          ::.:.
Frog   211 HEKNEDDEEIDLE-------SIDIDKIDDNDGEQSNEEEDEKLEHLRQGEKESFKKESEVMIPSS 268

  Fly   386 FGYPSAGSGSGGYPGGGGSSSG--HPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQTDLGDP 448
            .|..|..|.|.|......|::.  .|||                ||.:
Frog   269 DGLKSKDSLSLGKESSDTSNTRIVSPGG----------------QGNI----------------- 300

  Fly   449 KNQLGRDCGVPIPATKPKIWSLADTVGC------KTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQ 507
                    .|| |..||||||||:|...      .:|||:...|.|.|:|..            .
Frog   301 --------QVP-PHNKPKIWSLAETATSPDGALKSSPPPSQANHTSPPIQHP------------A 344

  Fly   508 YPPS------EAGRDQQLFNGAAAPY-----------LRPHTTAYGGF----------LGAT--- 542
            :.||      :.|:.....|||....           :.||..|:...          |.||
Frog   345 FLPSHGLYTCQIGKFHNWTNGAFLTQSSLINMRSLLGVNPHHVAHHNHHHLQAHQQAPLLATNLS 409

  Fly   543 ----------TQQLHTTNNSIPYSNMPPQQQ---QPQQQQQQLQQGGT 577
                      |...|:...::|.:..|||.:   |..::....||.||
Frog   410 SLSSDKTPERTSPKHSDRENLPRTESPPQLKPSFQAVRENTLSQQEGT 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
irx1	NP_001188351.1	Homeobox_KN	144..183	CDD:283551	37/38 (97%)
irx1	NP_001188351.1	IRO	303..320	CDD:214716	11/17 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.100