DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ara and irx5

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001165398.1	Gene:	irx5 / 100038201	XenbaseID:	XB-GENE-484376	Length:	486	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	175/564 - (31%)
Similarity:	232/564 - (41%)	Gaps:	173/564 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LALS---SYSRLPAASVGVYGTPY--------PSTDQ----------NPY---QSIGVDSSAFYS 199
            ||:|   .|...|:||:.:|..|.        |.||:          :||   .:....|:.|.|
Frog     3 LAMSYPQGYLYQPSASLALYSCPAYSTTVISGPRTDELGRSPSGSAFSPYAGSTAFTASSAGFNS 67

  Fly   200 PLSNPYGLKDTGAGPEMGAWT---------SAGLQPTTGYYSY-DPMSAYGGLLVSNSSYGASYD 254
            ||..        :|....|:|         |||:..:.||:.| .|:..|            .|.
Frog    68 PLQY--------SGDPAAAFTSYVGSPYDHSAGMAGSLGYHPYAAPLGTY------------PYG 112

  Fly   255 LAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKM 319
            ..|.||||||::|||||||||||:|||||||||||||||||||||||||||||||||||||||||
Frog   113 DPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKM 177

  Fly   320 TWEPKNRTDDDDDALVSDDEKDKED----LEPSKGSQ--------------------GSVSLAK- 359
            ||.|:||::|::|....|.||::||    || .||.|                    |.|...|
Frog   178 TWTPRNRSEDEEDDENIDLEKNEEDDPRKLE-EKGDQDGDAGDQKRSPSAVDFDRLEGEVRQGKE 241

  Fly   360 -DETK--EEEDAIDEDQKCLGQANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQ--- 418
             |:|:  .|::.::|....|.:.:........|...|     |......:.|....|.:|||
Frog   242 LDQTRSDSEQNEVEERNDLLSKNSAPPTSPLCPPDQS-----PQAQEDQNLHRHTVHNHHHQSIQ 301

  Fly   419 --HPAYYQAGQ----QGGMLPFHGENSKLQTD-LGDPKNQLGRDCGVPIPATKPKIWSLAD---- 472
              |...:|:..    ....|..||..:...|. :..|          |...:|||:||||:
Frog   302 QLHHHSHQSHPLDLVHRNALVQHGPVTNNATSVIHSP----------PASTSKPKLWSLAEIATS 356

  Fly   473 -----------TVGCKTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQYPPSEAGRDQQLFNGAAAP 526
                       .|...||..:.:...|.|        .:...||..: ||.....:.|:  .:.|
Frog   357 SDKVKESSDAAAVAGTTPAQSMVVSASSP--------SRSPSAQCHF-PSNTVLSRPLY--YSNP 410

  Fly   527 YLRPHTTAYGGFLGATTQQLHTTNNSIPYSNMPPQQQQPQQQQQQLQQGGTIHTTGSSSGPIIPL 591
            :. |..|.||.|     ..||        |:..|....|           |:::|...||  |..
Frog   411 FY-PGYTNYGTF-----SHLH--------SHHGPSTTSP-----------TVNSTHHFSG--INQ 448

  Fly   592 QFHNRHPQQQQQLQQQSQSTASQRAMGFLEAQPDTPPQTPPNMK 635
            ...||.....::.:.:|||            |.|....||..||
Frog   449 TVLNRAEALAKECKLRSQS------------QADLNKDTPYEMK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	37/38 (97%)
irx5	NP_001165398.1	Homeobox_KN	131..170	CDD:368670	37/38 (97%)
irx5	NP_001165398.1	IRO	340..357	CDD:214716	7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040