DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ara and irx4

DIOPT Version :9

Sequence 1:	NP_524045.2	Gene:	ara / 39439	FlyBaseID:	FBgn0015904	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001263621.1	Gene:	irx4 / 100038068	XenbaseID:	XB-GENE-480570	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	147/404 - (36%)
Similarity:	196/404 - (48%)	Gaps:	88/404 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SCCENGRPIMTD---PVSGQTVCSCQ-YDSARLALSSYSRLPAASVGVYGTPYPSTD-QNPYQSI 190
            :|||:....::|   ..|.||...|. |:|..||.:.:....||::||||:||.||. ...|.:.
Frog    25 TCCESSGRSLSDSAAAASAQTPVYCPVYESRLLATARHELNSAAALGVYGSPYTSTQGYGNYVTY 89

  Fly   191 GVDSSAFYSPLSNPYGLKDTGAGPEMGAWTSAGLQPTTGYYSYD-PMSAYGGLLVSNSSYGASYD 254
            |.|:|||||  .|.:..|| |.|.     ..||:..|..||.|: .:|.|     ....|| :.|
Frog    90 GADASAFYS--LNAFESKD-GTGS-----AHAGIPQTAAYYPYEHTLSQY-----QYDRYG-TMD 140

  Fly   255 LAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKM 319
            .:.||||||||:|:||||||.||:|||||||||||||||||||||||||||||||||||||||||
Frog   141 GSTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKM 205

  Fly   320 TWEPKNRTDDDDDALVSDDEKDKEDLEPSKGS--QGSVSLAKDETKEEEDAID----EDQKCLGQ 378
            ||.|:|:..|:....  |:|:::|:.|.|:.:  :....:..:|...|:.|:|    ||...:
Frog   206 TWPPRNKCSDEKRPY--DEEEEEEEEEDSQKATIKNEKKIVDEEVAREDKALDLSDLEDFDAI-- 266

  Fly   379 ANILRAGFGYPSAGSGSGGYPGGGGSSSGHPGGYHPYHHQHPAYYQAGQQGGMLPFHGENSKLQT 443
                                    .|.|.......|:|||....:|. :|...:..|.::..|:.
Frog   267 ------------------------ESESSECELKQPFHHQPQDGHQL-RQRDCVNDHCKDVILKM 306

  Fly   444 DLGDPKNQ---------------------LGRDCGVPIPA---------TKPKIWSLADTVGCKT 478
            .:....||                     .||..|....|         :||:|||||.|.....
Frog   307 PITPAANQELDRTKICHKPGVDQCEQDVLRGRQRGGESKACFQQQQILDSKPRIWSLAHTATSLN 371

  Fly   479 P---PPAYMGHQSM 489
            .   |...:.||.:
Frog   372 QTEYPSCMLKHQGL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ara	NP_524045.2	Homeobox_KN	273..312	CDD:283551	36/38 (95%)
irx4	NP_001263621.1	Homeobox_KN	159..198	CDD:368670	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..236		13/34 (38%)
		IRO	356..369	CDD:214716	8/12 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm9458
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.050