DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sowah and Sowahc

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001102834.1	Gene:	Sowahc / 503306	RGDID:	1595666	Length:	516	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	134/578 - (23%)
Similarity:	215/578 - (37%)	Gaps:	142/578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELSVAEIRNYMLANECKVTNHALVKHFKKFLTHPQSQ-NEARKRFKTYVTLLSTIKNE--NNQKF 67
            |.|...:..::.....:..:..||:||:..|...:.| ..||:.||..|..::|::.:  :..|:
  Rat     6 EPSSEAVLRFLAERGGRARHSELVQHFRDALCGKREQRTRAREHFKELVNAVATVRTDPADGTKY 70

  Fly    68 LILRKKYV------------NECPTDEVVERAVAAASGIPEPSSPGGASLNFDSPMRQPPPYKPP 120
            :.|:|::.            .:.|..||.|          ||..|       |.|.:.....:||
  Rat    71 VHLKKRFCMGESPPLEAALPQQLPRIEVTE----------EPQVP-------DLPAKPCEGSQPP 118

  Fly   121 PMVTSPPAVSI----AKEHQENYQECVDEFTAAIKRIEPARLERRTSVKSEDLDQQEKPEKTSRS 181
              |.:.|.:|:    ...||:                .||..:.....|    |...:.|..|.:
  Rat   119 --VEADPQLSLGVGGGLSHQK----------------PPAAAQGGAQSK----DSPREVEAVSWA 161

  Fly   182 NSIDVIDNKENIPRFSFSSEASSASSTSI-----------------EKPEMADPTAPAAVGDVAE 229
            ......:|.:..|.  ...||...||.|:                 ..|::.....|   ||.:.
  Rat   162 PGPGSSENLKLPPH--GGEEAEGGSSPSVPNTPRSARQNFRDLVMGSSPQLKRSAGP---GDGSA 221

  Fly   230 NPISVKEATRKFNRMASEEEAKIISPPAKKKPEKQLIEEKDSPEVTLAHPKAKEWIVSMAKANYQ 294
            ..||....:|   ..|..:...:.|..|::       |......||| .|....|::|.::..:.
  Rat   222 GSISSGGRSR---GGADSDSTSLASSSAEE-------ESSGGGSVTL-DPLEHAWMLSASEGKWD 275

  Fly   295 ELAKMASEYPELVKLQCPATGYTALHWAAKHGNEDVVKLIAG-----TYKADVNARTNGGYTPLH 354
            .|..:.:..|.|:..:...||:|.||||||||.::::.::..     ....::|||::||||.||
  Rat   276 SLIGLLTCEPGLLSKRDFITGFTCLHWAAKHGRQELLAMLVNFATKHHLPVNINARSSGGYTALH 340

  Fly   355 LATQFGRDNIFELLWNVYKANRDIMDWSGNKPLDYSRQRSSVSASTCSSEYAKYFFGA---DVGN 416
            ||...|...:.:||...|.|:.||.|:||.|...|        .|...:|..|...||   |.|:
  Rat   341 LAAMHGHVEVVKLLVGAYDADVDIRDYSGRKASQY--------LSESIAEEIKNLVGALDEDDGD 397

  Fly   417 SFR-------TLGFIESSQIT---------GGT----LGSALTRGKKRAQNRFATISGGSLGGVG 461
            |..       .|..:..|.||         |..    |....|.|.| |::.....||.|.|.:.
  Rat   398 SAAGRGSGRWRLSKVLPSHITHKLSPVVEDGADHHHHLAEGWTGGSK-AKDSGRKASGSSSGRIK 461

  Fly   462 GAVS--RSQSMTVSRRPKKQPGQPISGIFKPATEDGDLLPCEMEGQPVPFRGASTRRK 517
            ..::  |.::..:...|..:..:       |..|:|     |.|.:..|.||.|:..|
  Rat   462 PRLNKIRFRTQIIHTTPSFKDAE-------PTLEEG-----EEEEEERPLRGYSSSFK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	14/43 (33%)
		ANK	<315..393	CDD:238125	33/82 (40%)
		Ank_4	315..368	CDD:290365	22/57 (39%)
		ANK repeat	315..346	CDD:293786	12/35 (34%)
		ANK repeat	348..380	CDD:293786	15/31 (48%)
Sowahc	NP_001102834.1	PHA03418	73..>192	CDD:177646	31/159 (19%)
		Ank_2	266..366	CDD:403870	33/99 (33%)
		ANK repeat	296..332	CDD:293786	12/35 (34%)
		ANK repeat	334..366	CDD:293786	15/31 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4635
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1531345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46181
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3353
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970