DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sowah and Ank2

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	138/708 - (19%)
Similarity:	235/708 - (33%)	Gaps:	220/708 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QNEARKRFKTYVTLLSTIKNENNQKFLILRKKYVNECPTDEVVERAVAAASGIPE-----PSSPG 101
            |..:||...|..:.||. |.|:       |:...:.  |......|.|.:..|.|     .|||.
  Fly 10980 QTPSRKTINTDKSKLSN-KTES-------RRSVTSS--TSTTTSSASATSRVISEIHFERSSSPA 11034

  Fly   102 GASLNFDSPMRQP-----------PPYKPP----PMVTSP----PAVSIAKEHQENYQECVDEFT 147
            .:|:.::|   ||           |..|..    |..|||    |.:...|..::...:.....|
  Fly 11035 SSSIFYES---QPQGEGSRSTTPRPRVKTDVTRIPYNTSPRSFSPQLKTTKTDKKTVNQTKTTAT 11096

  Fly   148 AAIKRIEPARLERRTSVKSEDLDQQEKPEKTSRSNSIDVIDNKENIP------RFSFSSEASSAS 206
            .:||     .|..::|.|:|....||..||  |........::...|      |:..|.:.....
  Fly 11097 RSIK-----ELTEKSSKKTERFASQEHVEK--RKTPTPSATHRYMQPTLAHSMRYGLSGDGDIGQ 11154

  Fly   207 STSIEKPEM-ADPTAPAAVGDVAENPISVKEATRKFNRMASEEEAKIISPPAKKKPEKQLIEEKD 270
            :.::..|:. |.|.:|..         ::.::||:...:.|          |..|...|:.::|:
  Fly 11155 NVTLTSPKSPAPPKSPTP---------ALTKSTRRTQTITS----------ALTKSTSQITKQKN 11200

  Fly   271 S-PEVTLAHPK----------AKEWIVSMAKANYQ-------ELAKMASEYPELVKLQCPATGYT 317
            | .|:..|.|:          :||.::......|:       :||.:.....:..|.....:..:
  Fly 11201 SIAEMKQAQPRSQIKRGSQSDSKESLIKSTDRLYKRQTSKENKLANVIGSKSQATKSMKTQSANS 11265

  Fly   318 ALHWAAKHGNEDVVKLIAGT----------YKADVNARTNGGYTPLHLATQFGR--DNIFELLWN 370
            |....:|...|...||:..|          .....:|||         |.:..:  |.:
  Fly 11266 AKKLVSKTSIETDNKLLKKTTATIQRTKVPISVSSSART---------AAKLSKSDDTV------ 11315

  Fly   371 VYKANRDIMDWSGNKPLDYSRQRSSVSASTCSSEYAKYFFGADVGNSFRTLGFIESSQITGGTLG 435
                .|..:|  ..||:..:..:.|.|:.|                   |.....|::|...::.
  Fly 11316 ----KRPQVD--NKKPVKRTVSKVSESSGT-------------------TTTTTTSTRIVAKSME 11355

  Fly   436 SALTRGKKRAQNRFATISG-GSLGGVGGAVSRSQSM----TVSRRPKK----------------- 478
            ..|.:..|...|..::.|| |:....|.:.|..:|:    ||||:..|
  Fly 11356 PKLQKKMKDTMNESSSNSGSGTTSASGSSNSTRRSVRSVSTVSRKTDKDLTNIRRASGAVVSTST 11420

  Fly   479 -----QPGQPISGIFKPATEDGDLLPCEMEGQPVPFRGASTRRKESFLRKTFRATAGG--SRRPL 536
                 :|....|.:.....:|    .||:    :..|  |.:..:|....|..::..|  ||:.|
  Fly 11421 VRVHREPTATTSAVSTVLVDD----DCEV----ITIR--SIKSSDSTKSSTSSSSGSGSNSRKVL 11475

  Fly   537 AKDVFT-------------NPPEHEIK------ARKKHAIEKDLGFLRIGSLNVRVKKTTEAFSN 582
            ..:|||             ..||.:::      .|...|...|.... |...:|....||::
  Fly 11476 TSEVFTKTFGPDKPLEVVYRQPEFDVEHHTIMSVRPPSATSSDQQRC-INEFDVSFIDTTDS--- 11536

  Fly   583 FLGVGNGSGVAPTGYGNGGSAVAANRHHPRSHRAP----------------HQRHHHH 624
              .:.:...:...|.|:....:||:...|:..|:|                ||:||||
  Fly 11537 --SLSDSVALPMLGSGDPDRLLAASPGSPKPTRSPLALIEETLRRQQQHHHHQQHHHH 11592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	7/50 (14%)
		ANK	<315..393	CDD:238125	15/89 (17%)
		Ank_4	315..368	CDD:290365	11/64 (17%)
		ANK repeat	315..346	CDD:293786	7/40 (18%)
		ANK repeat	348..380	CDD:293786	3/33 (9%)
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030