Protein Alignment sowah and SOWAHB

DIOPT Version :10

• Sequence 1: NP_001137943.2
• Gene: sowah / 39438
• FlyBaseID: FBgn0036302
• Length: 780
• Species: Drosophila melanogaster
• Sequence 2: NP_001025041.1
• Gene: SOWAHB / 345079
• HGNCID: 32958
• Length: 793
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 135/722 - (18%)
• Similarity: 216/722 - (29%)
• Gaps: 335/722 - (46%)

  Fly     3 LPKELSVAEIRNYMLANECKVTNHALVKHFKKFLTHPQ---SQNEARKR-FKTYVTLLSTIKNE- 62
            :.:|||...:.:::.....:|||.||:.|||.||..|.   ||::.|:. ||.:|..::.::.:
Human     1 MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAVRQDP 65

  Fly    63 NNQKFLILRKKY---------------------------------------------------VN 76
            :..|:::|:::|                                                   ..
Human    66 DGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPE 130

  Fly    77 ECPTDEVVERAVAAASGIPEPSS---PGGASLNFDSPMRQPP----------------------- 115
            |.|.......|.||.:|:|...|   ||....:..||.::||
Human   131 EEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGR 195

  Fly   116 ------------------------------------------------------------PYKPP 120
                                                                        .:.||
Human   196 CCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPP 260

  Fly   121 PMV------TSPPAV-----------------SIAKEHQENYQECVDEFTAAIKRIEPARLE--- 159
            ..|      .||||:                 |:.....:..|:...|:.|...::..||.:
Human   261 ATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPI 325

  Fly   160 RRTSVKSEDLDQ-----------QEKPEKTSRSNSI----------------------------- 184
            |..||..::..|           .|.|:....|:|:
Human   326 RAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLS 390

  Fly   185 -----DVIDNKENIPRFSFSSEASS----------------------------ASSTSIEKPEMA 216
                 |.:|.:.:     .|.|:||                            |...|:.:.| .
Human   391 LQDLDDFVDQESD-----GSEESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKE-G 449

  Fly   217 DPT-----------------APAAVGDVAENPIS-----VKEATRKFNRMASEEEAKIIS----- 254
            .|:                 .||....:|.:|:.     |.:..|...|.:....||:.|
Human   450 SPSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEY 514

  Fly   255 -----------PPAKKKPEK---------------QLIEEKD----------------------S 271
                       ||..:||.|               :|.|.|.                      :
Human   515 LDEGLLKRSRRPPRSRKPSKAGTAPSPRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALA 579

  Fly   272 PEVTLAH--------PKAKEWIVSMAKANYQELAKMASEYPELVKLQCPATGYTALHWAAKHGNE 328
            |..|..|        .:..||||.:|..::.::..:..|.|:|...:...||||||||.||||:.
Human   580 PHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDL 644

  Fly   329 DVVK-LIAGTYKA----DVNARTNGGYTPLHLATQFGRDNIFELLWNVYKANRDIMDWSGNKPLD 388
            ..:: |::|..||    |||.|::.||||||||...|...:.:||.....:..::.|.||.||..
Human   645 RALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQ 709

  Fly   389 YSRQRSS 395
            |....:|
Human   710 YLTSNTS 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	HFD_SF	<126..>169	CDD:480273	12/62 (19%)
		ANKYR	<315..>393	CDD:440430	36/82 (44%)
		ANK repeat	315..346	CDD:293786	18/35 (51%)
		ANK repeat	348..380	CDD:293786	11/31 (35%)
SOWAHB	NP_001025041.1	CSB_WHD	2..78	CDD:439329	22/75 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..185		14/101 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..290		7/70 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..360		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..543		25/152 (16%)
		ANK 1	630..659		16/28 (57%)
		ANKYR	<631..723	CDD:440430	37/86 (43%)
		ANK repeat	631..667	CDD:293786	18/35 (51%)
		ANK repeat	669..701	CDD:293786	11/31 (35%)
		ANK 2	669..699		11/29 (38%)