DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sowah and ANK2

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001373103.1	Gene:	ANK2 / 287	HGNCID:	493	Length:	4183	Species:	Homo sapiens

Alignment Length:	944	Identity:	171/944 - (18%)
Similarity:	290/944 - (30%)	Gaps:	324/944 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DEVVERAVAAASGIPEPSSPGGASLNFDSPMRQPPPYKPPPMVTS----PPAVSIAKEHQENYQE 141
            |:.:|:.....|....|.||       |:|..:...|:..|..|.    .|||         ..|
Human  2566 DDSLEQTSLMESSGKSPLSP-------DTPSSEEVSYEVTPKTTDVSTPKPAV---------IHE 2614

  Fly   142 CVDE----------FT---------AAIKRIEPARLERRTSVKSEDLDQQEKPEKTSRSN----- 182
            |.:|          ||         ..||..:  .||:....| .|..::.|.|::|.|:
Human  2615 CAEEDDSENGEKKRFTPEEEMFKMVTKIKMFD--ELEQEAKQK-RDYKKEPKQEESSSSSDPDAD 2676

  Fly   183 -SIDVIDNK--------ENIPRFSFSSEASSASSTSIEKPEMA------------------DPTA 220
             |:||.:.|        ..:| ...:||:...||:|..:||:|                  .|.:
Human  2677 CSVDVDEPKHTGSGEDESGVP-VLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPS 2740

  Fly   221 P--------AAVGDVAENPISVKEATRKFNRMASEEEAK----------------IISPPAKKKP 261
            |        ::..:|...|:..|:.|.|.|....||..|                .:|..|:.:.
Human  2741 PLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRS 2805

  Fly   262 EKQLIEEKDSPEVTLAH------PKAKEWIVS--MAKANYQELAKMASEYPELVKLQ-------- 310
            ..:|..:.|.|::...|      |.:....||  :......::.:....|.|.:.||
Human  2806 YDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTE 2870

  Fly   311 ---------------CPATGYTAL----HWAAKHGNE--DVVKLIAGTYKADVNARTNGGYTPL- 353
                           ||:..:::.    |.....|.|  :.:...:...|.:| .:|:..:..|
Human  2871 GEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEV-TKTDETFENLP 2934

  Fly   354 --------HLATQFGRDNIFELLWNVYKANRDIMDWSGNKPLDYSRQRSS-----VSASTCSSEY 405
                    .:.||..|          :..:..:.|.:.|..: |..|.:|     .|.|..|||.
Human  2935 KDCPSQDSSITTQTDR----------FSMDVPVSDLAENDEI-YDPQITSPYENVPSQSFFSSEE 2988

  Fly   406 AKYFFGADVGNSFRT--------LGFIESSQITGGTLGSALTRG--------KKRAQ-------- 446
            :|....|:...||.:        ...:|...:...:.|:.|::.        |..:|
Human  2989 SKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEM 3053

  Fly   447 ------NRFATISGGSLGGVGGAVSR---------SQSMTVSRRPK-------KQPGQPISGIFK 489
                  :.|......:...||..:|:         |.|.:..|...       |:..|.|.|:..
Human  3054 QSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMV 3118

  Fly   490 PATEDG---DLLPCEM---EGQPVPFRGASTRRKESFL---RKTFRATAGGSRRPLAKDVFTNPP 545
            .....|   |..|...   ||.|       |..:..||   .|.|..|..|:
Human  3119 DRQSQGTTPDTTPARTPTEEGTP-------TSEQNPFLFQEGKLFEMTRSGA------------- 3163

  Fly   546 EHEIKARKKHAIEKDLGFLRIGSLNVRVKKTTEAFSNFLGVGNGSGVAPTGYGNGGSAVAANR-- 608
               |...|:...::...|.:||.     :...|..|..:..| .:|..|........::|.:.
Human  3164 ---IDMTKRSYADESFHFFQIGQ-----ESREETLSEDVKEG-ATGADPLPLETSAESLALSESK 3219

  Fly   609 ---------------HHPRSHRAPHQRHHHHVGTTRSRHPNQRAAMST-----PYATNGGLP--- 650
                           .......|...:.:..:|.:.|.....:.|:|.     |....|.:|
Human  3220 ETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLS 3284

  Fly   651 --SRASVPNS---------------RNIYDGVHKSWGSADNIPHRSEDLMPPPKA----VEYISK 694
              .:.|.|:|               |::|.  .:...|.|:.|...:.::..|.|    |.:...
Human  3285 GVKQISCPDSSEPAVQVQLDFSTLTRSVYS--DRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES 3347

  Fly   695 RNKSSKR-----------SSYASNTTDSPRDSICSSNSS---------------SNLNGGYSSMP 733
            ::|...|           :.|.|:.::....|:...|.:               ..:....|.:.
Human  3348 KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSDLD 3412

  Fly   734 TTPNQLRAPKG-IAASFAVDSDSDS---ACGFDS 763
            |:..:..||:| ..||.|.|:.|.|   |...||
Human  3413 TSVQKTVAPQGQDMASIAPDNRSKSESDASSLDS 3446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	9/72 (13%)
		ANK	<315..393	CDD:238125	13/92 (14%)
		Ank_4	315..368	CDD:290365	10/67 (15%)
		ANK repeat	315..346	CDD:293786	5/36 (14%)
		ANK repeat	348..380	CDD:293786	4/40 (10%)
ANK2	NP_001373103.1	Ank_2	35..>311	CDD:423045
		ANK repeat	80..111	CDD:293786
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..171	CDD:293786
		Ank_2	202..>444	CDD:423045
		ANK repeat	212..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..313	CDD:293786
		ANK repeat	315..345	CDD:293786
		ANK repeat	348..379	CDD:293786
		ANK repeat	381..411	CDD:293786
		ANK repeat	414..445	CDD:293786
		PHA03095	421..>706	CDD:222980
		ANK repeat	447..478	CDD:293786
		ANK repeat	480..511	CDD:293786
		ANK repeat	513..542	CDD:293786
		ANK repeat	546..571	CDD:293786
		Ank_2	578..>802	CDD:423045
		ANK repeat	579..604	CDD:293786
		ANK repeat	612..643	CDD:293786
		ANK repeat	645..676	CDD:293786
		ANK repeat	678..707	CDD:293786
		ANK repeat	711..742	CDD:293786
		ANK repeat	744..775	CDD:293786
		ANK repeat	777..806	CDD:293786
		Ank_4	778..830	CDD:372654
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PspC_subgroup_1	1549..>1922	CDD:411407
		PTZ00449	<1717..2161	CDD:185628
		Streccoc_I_II	<1843..>2027	CDD:411384
		Spc7_N	<2493..>2634	CDD:373822	19/83 (23%)
		rad2	<3031..>3565	CDD:273166	76/447 (17%)
		PRK14949	<3196..>3442	CDD:237863	40/248 (16%)
		Death_ank2	3614..3697	CDD:260066
		NESP55	<3770..>3884	CDD:115071
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030