DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sowah and Sowaha

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_898996.2	Gene:	Sowaha / 237761	MGIID:	2687280	Length:	548	Species:	Mus musculus

Alignment Length:	622	Identity:	156/622 - (25%)
Similarity:	235/622 - (37%)	Gaps:	174/622 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSVAEIRNYMLANECKVTNHALVKHFKKFLT--HPQSQNEARKRFKTYVTLLSTIKNENNQKFLI 69
            :|.|.:..::..:..:|.|..|:..||..|.  .|:.:...|.|||.:|..::.:|..:..||::
Mouse    16 VSQAAVLGFLREHGGQVRNSELLSRFKPLLDAGDPRGRAARRDRFKQFVNNVAVVKELDGVKFVV 80

  Fly    70 LRKK------YVNECPTDEVVERAVAAASGIP--EPSSPGGASLNFDSPMRQPPPYKPPPMVTSP 126
            ||||      .....|:...|..|:|..:.:|  :..:||..    .||.|.          ..|
Mouse    81 LRKKPRPPEGPEAPLPSSPGVPAALAQCAAVPAEDNCAPGAP----HSPQRS----------GEP 131

  Fly   127 PAVSIAKEHQENYQECVDEFTAAIKRIEPARLERRTSVKSEDLDQQEKPEKTSRSNSIDVIDNKE 191
            |..|.|                      |:.|:........::.|.|.|     |.|.......|
Mouse   132 PEDSSA----------------------PSELQHTPETLPSEVTQVEAP-----SGSAPQPGGPE 169

  Fly   192 N--IPRFSFSSEASSASS----TSIEK--PEMADPTA------------------PAAVGDVAEN 230
            :  :||.|..:..:|..|    ||.|.  ||.|.|||                  |||:...||.
Mouse   170 DPALPRSSELARPASVPSGLALTSTESPGPEPAPPTAQVPPQKPCMLPVRCVVPGPAALRIRAEE 234

  Fly   231 P---------------------ISVKEATRKFN---------RMASEEEAKIISPPAKKKPEKQL 265
            .                     :||:|:....:         |..|....:::||..::.|...|
Mouse   235 QGLRRQRSEEPSPRGSPMLLRRLSVEESGLGLHLGPGRSPHLRRLSRAGPRLLSPDTEEMPVAPL 299

  Fly   266 IEEKDSPEVTLAHPKAKEWIVSMAKANY-QELAKMASEYPELVKLQCPATGYTALHWAAKHGNED 329
                .||.|.| .|...||:|..|...: .:|..:......|...:...:|:||||||||:|:.:
Mouse   300 ----PSPAVPL-EPTEHEWLVRTASGRWSHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKNGDRE 359

  Fly   330 V-VKLI----AGTYKADVNARTNGGYTPLHLATQFGRDNIFELLWNVYKANRDIMDWSGNKPLDY 389
            : ::|:    .|....|||||::|||||||||...|.::...||.....|...:.|:||.:...|
Mouse   360 MALQLVEVARRGGAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDYSGRRAYQY 424

  Fly   390 SRQRSSVSASTCSSEYAKYFFGADVGNSFRTLGFIESSQITGGTLGSALTRGKKRAQNRFATISG 454
            .|..||         ||......|.|  .|::  :|....:||: ||.::|...:..   |||..
Mouse   425 LRPGSS---------YALRRLLGDPG--LRSM--MEPDAASGGS-GSLVSRHPVQVA---ATILS 472

  Fly   455 GSLGGVGGAVSRSQSM-TVSRRPKKQPGQPISGIFKPATEDGDLLPCEMEGQPVPFRGAS---TR 515
            .:.....|.::....: .::|..||      |..|.                  .|.|||   .|
Mouse   473 STTSAFLGVLADDLMLQDLARGLKK------SSSFS------------------KFLGASPMAPR 513

  Fly   516 RK-------ESFLRKTFRATAGGSRRPLAKDVFTNPP 545
            :|       .||...:.|:|.|    |||..|.:.||
Mouse   514 KKTKIRGGLPSFTEISHRSTPG----PLAGLVPSLPP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	13/45 (29%)
		ANK	<315..393	CDD:238125	35/82 (43%)
		Ank_4	315..368	CDD:290365	27/57 (47%)
		ANK repeat	315..346	CDD:293786	16/35 (46%)
		ANK repeat	348..380	CDD:293786	13/31 (42%)
Sowaha	NP_898996.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..212		31/138 (22%)
		ANK repeat	344..381	CDD:293786	16/36 (44%)
		ANK 1	344..373		12/28 (43%)
		ANK	345..>437	CDD:238125	39/100 (39%)
		Ank_4	345..404	CDD:290365	28/58 (48%)
		ANK repeat	383..415	CDD:293786	13/31 (42%)
		ANK 2	383..413		13/29 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..548		13/39 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4658
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1531345at2759
OrthoFinder	1	1.000	-	-		FOG0004238
OrthoInspector	1	1.000	-	-		otm44088
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	6.020