DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sowah and unc-44

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001367345.1	Gene:	unc-44 / 177366	WormBaseID:	WBGene00006780	Length:	6994	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	119/609 - (19%)
Similarity:	194/609 - (31%)	Gaps:	206/609 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LERRTSVKSEDLDQQEKPEKTSRSNSIDVIDNKENIPRFSFSSEASSASST---------SIEKP 213
            |||.|.|..|..:|.......:..|:       :.:......:.||:.::.         :.:|.
Worm   577 LERGTPVDIEGKNQVTPLHVAAHYNN-------DKVAMLLLENGASAKAAAKNGYTPLHIAAKKN 634

  Fly   214 EM----------ADPTAPAAVGDVAENPISVKEATRKFNRMASEEEAKIISPPAKKKPEKQLIEE 268
            :|          |||.|.:..|....: :|.:|..::.:.:..|..:.              :..
Worm   635 QMEIASTLLQFKADPNAKSRAGFTPLH-LSAQEGHKEISGLLIENGSD--------------VGA 684

  Fly   269 KDSPEVTLAHPKAKEWIVSMAKANYQELAKMASEYPELVKLQCPATGYTALHWAAKHGNEDVVKL 333
            |.:..:|..|..|:|..|.:|:..|...|::.|:         ...|||.||.|...|..::||.
Worm   685 KANNGLTAMHLCAQEDHVPVAQILYNNGAEINSK---------TNAGYTPLHVACHFGQLNMVKF 740

  Fly   334 IAGTYKADVNARTNGGYTPLHLATQFGRDN-IFELLWNVYKANRDIMDWSGNKPLDYSRQRSSVS 397
            :... .|||..:|...|||||.|.|.|.:| :..||.|....|....  :|..||..:::...||
Worm   741 LVEN-GADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTA--TGQTPLSIAQRLGYVS 802

  Fly   398 ASTCSSEYAKYFFGADVGNSFRTLGFIESSQITGGTLGSALTRGKKRAQNRFATISGGSLGGVGG 462
                            |..:.||:  .|::.||
Worm   803 ----------------VVETLRTV--TETTVIT-------------------------------- 817

  Fly   463 AVSRSQSMTVSRRPKKQPGQPISGIFKPATEDGDLLPCEMEGQPVPFRGASTRRK---------- 517
                 ::.||..|.|.|..:.::......:||        |||.......:...|
Worm   818 -----ETTTVDERYKPQNPEAMNETMFSESED--------EGQAAEHEAVAAHEKDFSDNLTQGL 869

  Fly   518 ------------ESFLRKTFRATAGGSRRPLAKDVFTNPPEHE------IKARKKHAIEKDLGF- 563
                        |..|:::.....||:...:.....:  ||.|      :......|......|
Worm   870 QDSTGVHMIHTGEQLLQRSQELENGGAIPKINSGGMS--PEKEFAKIAPVATSSPIATSNSQSFG 932

  Fly   564 --LRIGSLNVRVKK---------------TTEAFSNFLGVGNGSGVAPTGYGNGGSAVAANRHHP 611
              .|.||::.:.::               ...|.::.:..||        |.|||.|:..|.|
Worm   933 IAPRAGSISGQFQQQPLHGAGPEDNLEELVRRAQNHPINAGN--------YDNGGVAMLENGH-- 987

  Fly   612 RSHRAPHQRHHHHVGTTRSRHPNQRAAMSTPYATNGGL--------------PSRASVPNSRNIY 662
                |.:....||| |..|:..::...:|......||.              |.:||.|..
Worm   988 ----ADNVPIGHHV-TQPSKLQHRTFLISFLVDARGGAMRGCRHSGVRIIVPPRKASQPIR---- 1043

  Fly   663 DGVHKSWGSADNIPHRSEDLMPPP 686
              |...:...|.:.|      |||
Worm  1044 --VTCRYLRKDKLAH------PPP 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	12/43 (28%)
		ANK	<315..393	CDD:238125	29/78 (37%)
		Ank_4	315..368	CDD:290365	22/53 (42%)
		ANK repeat	315..346	CDD:293786	12/30 (40%)
		ANK repeat	348..380	CDD:293786	13/32 (41%)
unc-44	NP_001367345.1	ANK repeat	32..63	CDD:293786
		PHA03095	37..>387	CDD:222980
		ANK repeat	65..96	CDD:293786
		ANK repeat	98..129	CDD:293786
		ANK repeat	131..156	CDD:293786
		ANK repeat	197..224	CDD:293786
		ANK repeat	226..257	CDD:293786
		PHA02876	<242..>648	CDD:165207	12/77 (16%)
		ANK repeat	259..290	CDD:293786
		ANK repeat	292..322	CDD:293786
		ANK repeat	325..356	CDD:293786
		ANK repeat	358..389	CDD:293786
		ANK repeat	391..422	CDD:293786
		ANK repeat	424..455	CDD:293786
		ANK repeat	457..488	CDD:293786
		ANK repeat	490..519	CDD:293786
		ANK repeat	523..552	CDD:293786
		Ank_2	555..>780	CDD:423045	55/234 (24%)
		ANK repeat	556..586	CDD:293786	5/8 (63%)
		ANK repeat	589..620	CDD:293786	4/37 (11%)
		ANK repeat	622..652	CDD:293786	5/29 (17%)
		ANK repeat	655..685	CDD:293786	4/44 (9%)
		ANK repeat	688..719	CDD:293786	9/39 (23%)
		ANK repeat	721..752	CDD:293786	12/31 (39%)
		ANK repeat	754..784	CDD:293786	13/29 (45%)
		Ank_4	756..807	CDD:372654	19/68 (28%)
		ZU5	1008..1110	CDD:128514	13/64 (20%)
		UPA_2	1337..1472	CDD:375346
		Death_ank	1503..1580	CDD:260029
		PTZ00449	<1770..2112	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030