DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sowah and Ank2

DIOPT Version :9

Sequence 1:	NP_001137943.2	Gene:	sowah / 39438	FlyBaseID:	FBgn0036302	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_036018747.1	Gene:	Ank2 / 109676	MGIID:	88025	Length:	4152	Species:	Mus musculus

Alignment Length:	944	Identity:	175/944 - (18%)
Similarity:	286/944 - (30%)	Gaps:	306/944 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 THPQSQNEARKRFKTYVTLLSTIKNENNQKFLILRKKYVNECPTDEVVERAVAAASGIPEPSSPG 101
            |..:.:..|:|:.|..:.:...::.:       |::|...:..:.:..|.......|..|.|...
Mouse  1729 TSAEEKQSAQKQLKPGLAIKKPVRRK-------LKEKQKQKEESSQSSEEKTELKKGSSEESVDE 1786

  Fly   102 GASLNFDSPMRQPPPYKPPPMVTSPPAVSIAKEHQENYQECVDEFTAAIKRIEPARLERRTSVKS 166
            ...|   .|...|......|::...|..||.           |:..|..||:|
Mouse  1787 DRGL---VPEPLPTAKATSPLIEETPIGSIK-----------DKVKALQKRVE------------ 1825

  Fly   167 EDLDQQEKPEKTSRSNSIDVIDNKENIPR---------FSFSSEASSASS-------TSIEKPEM 215
               |:|:     .||.....:..||::|:         .|.||::|::|.       :|..|||.
Mouse  1826 ---DEQK-----GRSKLPVRVKGKEDVPKRTTPRTHPAVSPSSKSSTSSKAERHSSLSSSAKPER 1882

  Fly   216 ADPTAPAAVGDVAENPISVKEATRKFNRMASEEEAKII--SPPAKKK---PEKQLIEEKDSPEV- 274
            ..|.:|::..:.. :|:|....|.:.:.:.|.:..|..  ||..|.:   |...|..|:.:|..
Mouse  1883 HTPVSPSSKNEKL-SPVSPSAKTERHSPVFSGKPEKHSPGSPSTKNERHSPVSSLKTERHTPGSP 1946

  Fly   275 ---------------TLAHPKAKEWIVSMAKANYQELAKMASEYPELVKLQCP-------ATGYT 317
                           |..||....             .|.....|....::.|       |||..
Mouse  1947 SGKTDKRPPVPSSGRTEKHPPVSP-------------GKTEKHLPGSPSIRTPEKPAPGSATGKH 1998

  Fly   318 ALHWAAKHGNEDVVKLIAGTYKADVNARTNGGYTPLHLATQFGRD------NIFELLWNVYKANR 376
            ..|.....|..:....|:.|.|.:....|. ....|..|.|.|:|      .:||     :|:.:
Mouse  1999 EKHLPVSPGKTEKQPPISPTSKTERIEETM-SVRELMKAFQSGQDPSKHKTGLFE-----HKSAK 2057

  Fly   377 DIMDWSGNKPLDYSRQR---------SSVSASTCSSEYAKYFFGADVGNSFRTLGFIESSQITGG 432
            .      .:|.|.|:.|         :........|:.||.      |..|:.....||.:....
Mouse  2058 Q------KQPQDKSKSRVEKEKGHTVTQRETQRIESQTAKR------GQRFQVSAATESRRFRST 2110

  Fly   433 TLGSALTRGKKRAQNRF-------------ATISGGSLGGVGGAVSRSQSMTVSRRPKKQPGQPI 484
            |:...| |.:...:.||             :..:..|..|....|.....|.....|.::.....
Mouse  2111 TITVGL-RMEDPVRERFERTPIIKTPEVVPSVAAEESHRGSEKIVDEQGDMDFQISPDRKTSTDF 2174

  Fly   485 SGIFKPATEDGD-----LLPCEMEGQPV--------PFRGA--STRRKESFL-RKTFRATA-GGS 532
            |.:.|...||.|     .|..:.|...|        ||..|  ....|:.|| ..:.::.| |||
Mouse  2175 SEVIKQELEDNDKYQQFRLTEDTEKAQVHLDQVITSPFNTAFPLDYMKDEFLPALSLQSGALGGS 2239

  Fly   533 RRPLAKDVFTNPP-----------------EHEIKARKKHAIEKDLGFL------RIGSLNVRVK 574
            ...|.::|....|                 :||..|.......:.|.|.      :||    ..|
Mouse  2240 SESLKQEVIAGSPCSSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIG----EAK 2300

  Fly   575 KTTEAFSNFLGVGNGSGVAPTGYGNGGSAVAANRHHPRSHRAPHQRHHHHVGTTRSRHP----NQ 635
            :||:       ||     .||.       :.:.:..|.::...........|.||...|    :|
Mouse  2301 ETTK-------VG-----TPTD-------IHSEKELPITNDITDSSQKQGAGVTRGSEPSTEHSQ 2346

  Fly   636 RAAMSTPY----ATNGGLPSRASVPNSRNIY--------------------------------DG 664
            :.....|:    :...|.|...||..:..::                                ..
Mouse  2347 KEVTQDPHKDVCSKQDGCPESQSVSLASEVFTEKGSCGESQLPLVSSAFKTQSESETQESLTPSE 2411

  Fly   665 VHKSWGSAD-------------------------NIPHRSEDLMPPPKAVEYISKRNKSSKRSS- 703
            |.|.:..:|                         .:|:|..::: .|.|.|.::..:|.|..:|
Mouse  2412 VTKPFPPSDASVKTAEGTEPKPQGAIRSPQGLELPLPNRDSEVL-SPMADESLAVSHKDSLEASP 2475

  Fly   704 ----YASNTT----------DSP-RDSICSSNSSSNLNGGYSSMPTTPNQLRAPKGIAASFAVDS 753
                .:|:.|          :|| |||:.||.....:..|     ..|:....|..||.:..|..
Mouse  2476 VLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAG-----ILPSHFPLPAAIAKTDLVAE 2535

  Fly   754 ----------DSDSACGFDSTWSVNCRGSSSSNP 777
                      |.|.:...||....:...||..:|
Mouse  2536 VASMRSRLLRDPDGSAEDDSLEQTSLMESSGKSP 2569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sowah	NP_001137943.2	Ank_4	289..333	CDD:290365	8/50 (16%)
		ANK	<315..393	CDD:238125	18/83 (22%)
		Ank_4	315..368	CDD:290365	14/58 (24%)
		ANK repeat	315..346	CDD:293786	6/30 (20%)
		ANK repeat	348..380	CDD:293786	8/37 (22%)
Ank2	XP_036018747.1	PHA03095	46..>354	CDD:222980
		ANK repeat	80..111	CDD:293786
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..171	CDD:293786
		Ank_2	202..>444	CDD:423045
		ANK repeat	212..247	CDD:293786
		ANK repeat	249..280	CDD:293786
		ANK repeat	282..313	CDD:293786
		ANK repeat	315..345	CDD:293786
		ANK repeat	348..379	CDD:293786
		ANK repeat	381..411	CDD:293786
		ANK repeat	414..445	CDD:293786
		PHA03095	421..>706	CDD:222980
		ANK repeat	447..478	CDD:293786
		ANK repeat	480..511	CDD:293786
		ANK repeat	513..542	CDD:293786
		ANK repeat	546..571	CDD:293786
		Ank_2	578..>802	CDD:423045
		ANK repeat	579..604	CDD:293786
		ANK repeat	612..643	CDD:293786
		ANK repeat	645..676	CDD:293786
		ANK repeat	678..707	CDD:293786
		ANK repeat	711..742	CDD:293786
		ANK repeat	744..775	CDD:293786
		ANK repeat	777..806	CDD:293786
		Ank_4	778..830	CDD:372654
		ZU5	1013..1150	CDD:128514
		UPA_2	1371..1500	CDD:375346
		PHA03307	1823..>2031	CDD:223039	47/242 (19%)
		PTZ00449	<2261..2668	CDD:185628	58/338 (17%)
		COG5665	<2758..>2989	CDD:227952
		PHA03307	3210..>3537	CDD:223039
		Death_ank2	3595..3678	CDD:260066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030