DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4069 and KEL1

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_012028.1	Gene:	KEL1 / 856563	SGDID:	S000001201	Length:	1164	Species:	Saccharomyces cerevisiae

Alignment Length:	726	Identity:	139/726 - (19%)
Similarity:	225/726 - (30%)	Gaps:	263/726 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKDKNKKKGKGAEKTAMKTDKKQAARQKKMLEKL------------------GEANIADIIQLLE 49
            ||..:||.||.....::....::|:......||.                  ...|......:..
Yeast     8 KKFTHKKHGKTPSDASISDQSREASLSTPPNEKFFTKQETPQKGRQFSQGYHSNVNKTSSPPMFA 72

  Fly    50 AKEGKIEAISESVCPP---------------------------------PTPRSNFTLVCH-PEK 80
            .|:.....|..|..||                                 |.||.......: .:|
Yeast    73 RKQVSESRIQPSAVPPQQRNVSGPSTTLHKQLSKQREYTVWNRIKLQNSPFPRYRHVASAYVTDK 137

  Fly    81 EELIMFGG----ELYTGT-KTTVYNDLFFYNTKTVEWRQLKSPSGPTPRSGHQMVAVASNGGELW 140
            .::.:.||    .:|..| ..|.:::...::|.|::    .|.:.|.||.||..|..   |....
Yeast   138 NQIYVIGGLHDQSVYGDTWILTAFDNATRFSTTTID----ISEATPPPRVGHAAVLC---GNAFV 195

  Fly   141 MFGGEHASPSQLQFHHYK-------DLWKFALKSRKWERIAAPNGPSP--RSGHRMTV-----SK 191
            :|||:        .|...       |::...:.|.|| .:.||.||.|  |.||::::     .|
Yeast   196 VFGGD--------THKVNKEGLMDDDIYLLNINSYKW-TVPAPVGPRPLGRYGHKISIIATTQMK 251

  Fly   192 KRLFIFGGFHDNNQSYHYFNDVHIFSLESY-------QWLKAEIGGAIVPSPRSGCCIAASPEGK 249
            .:|::|||..|:.    ||||:.::.|.|:       ::||..   ...|.|.:...: .|.:.|
Yeast   252 TKLYVFGGQFDDT----YFNDLAVYDLSSFRRPDSHWEFLKPR---TFTPPPITNFTM-ISYDSK 308

  Fly   250 IYVWGGYSRAAMKKEA-------------------------DRGVTHTDMFVLSQDKNAGDA--D 287
            ::|:||.:...:..:.                         ...|.:.|:..:...|:..||  :
Yeast   309 LWVFGGDTLQGLVNDVFMYDPAINDWFIIDTTGEKPPPVQEHATVVYNDLMCVVGGKDEHDAYLN 373

  Fly   288 NKY-------KW--APVKPGGYKPKPRSSVGCTVAANGKAYTFGG-------VMDVDEDDEDVHG 336
            :.|       ||  .||...|. |:.||....|:..|.|....||       |.:.|....|:..
Yeast   374 SVYFLNLKSRKWFKLPVFTAGI-PQGRSGHSLTLLKNDKILIMGGDKFDYARVEEYDLHTSDIDM 437

  Fly   337 QFGDDLLAFDLT----------------------------------------------------- 348
            |.|..:...||.
Yeast   438 QRGTIVYTLDLARIKDLCPGVMDVPTDTPTPRNGNLDLATPVTPTSHQTKNMNVPISAAPLASAP 502

  Fly   349 -------SQTWRL-QEIQTKSSSAEKKDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGPSTST-- 403
                   |...|| :|:..::.|.|.::.....:.|...:.:|      .|.|..|...|:.|
Yeast   503 SPAPKDFSDADRLNREVHNRNVSTEHQNQSHPVNSESHLIAEP------NILTPYVPSESSQTPV 561

  Fly   404 ----------TPFVSKIPSLFAKPKPT----NVPS----PRMNPGMCVCKGTLYIF--------- 441
                      ||.:.|.|.|.....||    .:||    ..:.|...: |....|.
Yeast   562 MKITSNKPFDTPTIQKEPDLSETMDPTVGNQRIPSSIYGDNLTPANQI-KNNSPILETLPSNEIK 625

  Fly   442 ----GGIFEEDDKQLTYNDFYALDLHKLEWKVLIPNSLKGHEWEDSDSSSSDEECSGSEED---- 498
                |.|  |:.|.|...|      .|::........:.|.:...|..|..:|:.:.::||
Yeast   626 TPQNGNI--EEIKHLPDAD------EKIDSTTTFDQEINGDKLGTSSMSKVEEDGNVADEDDEIG 682

  Fly   499 ----ISSSSSD 505
                .||.|.|
Yeast   683 VAQMASSPSKD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	10/56 (18%)
		Kelch_3	80..132	CDD:290151	15/56 (27%)
		KELCH repeat	124..179	CDD:276965	15/61 (25%)
		Kelch_3	136..189	CDD:290151	17/61 (28%)
		Kelch_3	191..244	CDD:290151	16/59 (27%)
		Kelch_2	237..297	CDD:284956	15/95 (16%)
		KELCH repeat	305..353	CDD:276965	15/114 (13%)
		Kelch_5	423..463	CDD:290565	11/56 (20%)
		KELCH repeat	426..470	CDD:276965	10/56 (18%)
KEL1	NP_012028.1	Kelch_5	122..163	CDD:404696	9/40 (23%)
		KELCH repeat	125..179	CDD:276965	10/57 (18%)
		PLN02153	179..420	CDD:177814	63/261 (24%)
		KELCH repeat	182..233	CDD:276965	16/62 (26%)
		KELCH repeat	237..293	CDD:276965	17/62 (27%)
		KELCH repeat	299..345	CDD:276965	5/46 (11%)
		KELCH repeat	347..396	CDD:276965	11/49 (22%)
		Smc	<767..1078	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940