DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4069 and KEL2

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_011754.3	Gene:	KEL2 / 853153	SGDID:	S000003470	Length:	882	Species:	Saccharomyces cerevisiae

Alignment Length:	396	Identity:	88/396 - (22%)
Similarity:	138/396 - (34%)	Gaps:	123/396 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 NTKTVEWRQLKSPSGPTPRSGHQMVAVASNGGELWMFGGEHASPSQLQFHHYKDLWKFALK---- 166
            ||....|.::|..:.|.||..|....:.:|...:::.||.|....      |.|:|:.|..
Yeast    67 NTGKYIWNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGLHDQSV------YGDVWQIAANADGT 125

  Fly   167 SRKWERI-AAPNGPSPRSGHRMTVSKKRLFIFGG-FHDNNQSYHYFNDVHIFSLESYQWLKAEIG 229
            |...:|| ...|.|.||.||..|:......:||| .|..|::....:|:::|::.||:|
Yeast   126 SFTSKRIDIDQNTPPPRVGHASTICGNAYVVFGGDTHKLNKNGLLDDDLYLFNINSYKW------ 184

  Fly   230 GAIVPSP-------RSG---CCIAASP-EGKIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNA 283
              .:|.|       |.|   ..||::| :.|:|::||        :.|. ....|:.|.  |.::
Yeast   185 --TIPQPIGRRPLGRYGHKISIIASNPMQTKLYLFGG--------QVDE-TYFNDLVVF--DLSS 236

  Fly   284 GDADNKYKWAPVKPGGYKPKPRSSVGCTVAANGKAYTFGGVMDVDEDDEDVHGQFGDDLLAFDLT 348
            ....|.: |..::|.|..|.|.:: ...||.:.|.:.|||         :......:|...:|..
Yeast   237 FRRPNSH-WEFLEPVGDLPPPLTN-HTMVAYDNKLWVFGG---------ETPKTISNDTYRYDPA 290

  Fly   349 SQTWRLQEIQTKSSSAEKKDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGPSTSTTPFVSKIPSL 413
            ...|                                                       ||:.:.
Yeast   291 QSEW-------------------------------------------------------SKVKTT 300

  Fly   414 FAKPKPTNVPSPRMNPGMCVCKGTLYIFGGIFEEDDKQLTYNDFYALDLHKLEWKVL------IP 472
            ..||.|.      ......|.|..:.:.||   :|......||.|.|:|..|:|..|      ||
Yeast   301 GEKPPPI------QEHASVVYKHLMCVLGG---KDTHNAYSNDVYFLNLLSLKWYKLPRMKEGIP 356

  Fly   473 NSLKGH 478
            ....||
Yeast   357 QERSGH 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	4/13 (31%)
		Kelch_3	80..132	CDD:290151	8/25 (32%)
		KELCH repeat	124..179	CDD:276965	14/59 (24%)
		Kelch_3	136..189	CDD:290151	16/57 (28%)
		Kelch_3	191..244	CDD:290151	15/63 (24%)
		Kelch_2	237..297	CDD:284956	15/63 (24%)
		KELCH repeat	305..353	CDD:276965	8/47 (17%)
		Kelch_5	423..463	CDD:290565	9/39 (23%)
		KELCH repeat	426..470	CDD:276965	12/43 (28%)
KEL2	NP_011754.3	Kelch_5	82..116	CDD:404696	10/39 (26%)
		PLN02153	139..379	CDD:177814	68/318 (21%)
		KELCH repeat	142..190	CDD:276965	15/55 (27%)
		KELCH repeat	257..308	CDD:276965	14/121 (12%)
		KELCH repeat	310..353	CDD:276965	13/45 (29%)
		Smc	<603..>882	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940