DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4069 and LZTR1

DIOPT Version :9

Sequence 1:NP_648590.1 Gene:CG4069 / 39437 FlyBaseID:FBgn0036301 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_006758.2 Gene:LZTR1 / 8216 HGNCID:6742 Length:840 Species:Homo sapiens


Alignment Length:496 Identity:119/496 - (23%)
Similarity:193/496 - (38%) Gaps:120/496 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 ADIIQLLEAKEGKIEAISESVCPPP------TPRSNFTLVCHPEKEELIMFGGELYTGTKTTVYN 100
            :|.::.|....|..|.:......||      ..||..|:|.:  |:.:.:|||:    ...|:.|
Human    35 SDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAY--KDAIYVFGGD----NGKTMLN 93

  Fly   101 DLFFYNTKTVEW-RQLKSPSGPTPRSGHQMVAVASNGGELWMFG---GEHASPSQLQFHHYKDLW 161
            ||..::.|...| |...:.:.|.||..|..|..   |..:::||   |:..|.|.|:  :..||:
Human    94 DLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVY---GSSMFVFGGYTGDIYSNSNLK--NKNDLF 153

  Fly   162 KFALKSRKWE------RIAAPNGPSPRSGHRMTVSKKRLFIFGGFHDNNQSYHYFNDVHIFSLES 220
            ::...:.:|.      |:     |..||.|..||...:|:||.|:..|.:    .||:....|:.
Human   154 EYKFATGQWTEWKIEGRL-----PVARSAHGATVYSDKLWIFAGYDGNAR----LNDMWTIGLQD 209

  Fly   221 YQ---WLKAEIGGAIVPSPRSGCC---IAASPEGKIYVWGGYSRAAMKKEADRGVTHTDMFVLS- 278
            .:   |.:....|.|.||    ||   :|...: |::|:.|.|.|.:.         .::|... 
Human   210 RELTCWEEVAQSGEIPPS----CCNFPVAVCRD-KMFVFSGQSGAKIT---------NNLFQFEF 260

  Fly   279 QDKNAGDADNKYKWAPVKP----GGYKPKPRSSVGCT-VAANGKAYTFGGVMDVDEDDEDVHGQF 338
            :||.         |..:..    .|..|.|:...|.| ||.:...|.|||..|         ...
Human   261 KDKT---------WTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAAD---------NTL 307

  Fly   339 GDDLLAFDLTSQTWRLQEIQTKSSSAEKKDSEESKDVEMSAVDKPVTTTTDGIFTVTVG------ 397
            .::|..:|:..|||   |:...||.:|...:|..   |.:...:.|.|.|   :...||      
Human   308 PNELHCYDVDFQTW---EVVQPSSDSEVGGAEVP---ERACASEEVPTLT---YEERVGFKKSRD 363

  Fly   398 --GPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPGMCVCKGTLYIFGGIFEEDDKQLTYNDFYAL 460
              |....||.  :|.|:..|    :.:||.|:.....|....:|||||..:        |:..:.
Human   364 VFGLDFGTTS--AKQPTQPA----SELPSGRLFHAAAVISDAMYIFGGTVD--------NNIRSG 414

  Fly   461 DLHKLEWKVLIPNSLK---GHEWEDSDSSSSD------EEC 492
            ::::.::......:|.   |..||.......:      |||
Human   415 EMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEEC 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4069NP_648590.1 KELCH repeat 69..120 CDD:276965 15/51 (29%)
Kelch_3 80..132 CDD:290151 16/52 (31%)
KELCH repeat 124..179 CDD:276965 14/63 (22%)
Kelch_3 136..189 CDD:290151 15/61 (25%)
Kelch_3 191..244 CDD:290151 15/58 (26%)
Kelch_2 237..297 CDD:284956 12/63 (19%)
KELCH repeat 305..353 CDD:276965 13/48 (27%)
Kelch_5 423..463 CDD:290565 10/39 (26%)
KELCH repeat 426..470 CDD:276965 8/43 (19%)
LZTR1NP_006758.2 PLN02193 <44..223 CDD:330882 50/198 (25%)
KELCH repeat 68..114 CDD:276965 15/51 (29%)
Kelch 1. /evidence=ECO:0000255 79..128 15/55 (27%)
KELCH repeat 118..172 CDD:276965 14/63 (22%)
Kelch 2. /evidence=ECO:0000255 130..185 16/61 (26%)
PLN02193 160..>407 CDD:330882 76/302 (25%)
Kelch 3. /evidence=ECO:0000255 187..238 16/58 (28%)
Kelch 4. /evidence=ECO:0000255 239..285 12/63 (19%)
KELCH repeat 284..326 CDD:276965 15/53 (28%)
Kelch 5. /evidence=ECO:0000255 295..341 16/60 (27%)
Kelch 6. /evidence=ECO:0000255 399..450 10/58 (17%)
BTB 433..573 CDD:321966 6/23 (26%)
SPOP_C_like 574..634 CDD:269810
BTB 665..753 CDD:306997
SPOP_C_like 768..>807 CDD:269810
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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