Protein Alignment CG4069 and Klhdc2

DIOPT Version :10

• Sequence 1: NP_648590.1
• Gene: CG4069 / 39437
• FlyBaseID: FBgn0036301
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_081393.2
• Gene: Klhdc2 / 69554
• MGIID: 1916804
• Length: 406
• Species: Mus musculus
• Alignment Length: 320
• Identity: 77/320 - (24%)
• Similarity: 120/320 - (37%)
• Gaps: 78/320 - (24%)

  Fly   179 PSPRSGHRMTVSKKRLFIFGGFHDNNQS--YHYF---NDVHIFSLESYQWLKAEIGGAIVPSPRS 238
            |:.||||......:.:|::||:..|...  |.::   .::.|:::|:.:|.|....|.:.||...
Mouse    29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSG 93

  Fly   239 GCCIAASPEGKIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPK 303
            .|.:..  :..:|::||:.        .||  :|:.|.:...::   ||...:|..:...|..|.
Mouse    94 SCAVCV--DRVLYLFGGHH--------SRG--NTNKFYMLDSRS---ADRGLQWERIDCQGIPPS 143

  Fly   304 PRSSVGCTVAANGKAYTFGGVMDVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQTKSSSAEK-- 366
            .:..:|..|..| |...|||...:.||  .|.|.|     .||.|| .|        :||..:
Mouse   144 SKDKLGVWVYKN-KLIFFGGYGYLPED--KVLGTF-----EFDETS-FW--------NSSHPRGW 191

  Fly   367 KDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPGM 431
            .|.....|.|..|..:|:||                                 ...||||.....
Mouse   192 NDHVHILDTETFAWSQPITT---------------------------------GKAPSPRAAHAC 223

  Fly   432 CVCKGTLYIFGGIFEEDDKQLTYNDFYALDLHKLEWKVLIPNSL--KGHEWEDSDSSSSD 489
            .......::|||.:    :....||.:.|:|...||..|||..:  .|..|......|||
Mouse   224 ATVGNKGFVFGGRY----RDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSD 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	NanM	64..353	CDD:442289	46/178 (26%)
		KELCH repeat	69..120	CDD:276965
		KELCH repeat	124..179	CDD:276965	77/320 (24%)
		KELCH repeat	305..353	CDD:276965	16/47 (34%)
		Kelch_5	423..463	CDD:433528	10/39 (26%)
		KELCH repeat	426..470	CDD:276965	10/43 (23%)
Klhdc2	NP_081393.2	Kelch 1. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	31..85		13/53 (25%)
		KELCH repeat	32..91	CDD:276965	15/58 (26%)
		Kelch_4	32..89	CDD:433191	14/56 (25%)
		NanM	78..341	CDD:442289	65/271 (24%)
		KELCH repeat	92..138	CDD:276965	11/60 (18%)
		Kelch 2. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	92..136		11/58 (19%)
		Kelch 3. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	148..207		23/75 (31%)
		KELCH repeat	218..265	CDD:276965	13/50 (26%)
		Kelch 4. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	221..259		9/41 (22%)
		Kelch 5. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	271..311		3/9 (33%)
		Kelch 6. /evidence=ECO:0000250|UniProtKB:Q9Y2U9	322..359