Protein Alignment CG4069 and KLHDC4

DIOPT Version :10

• Sequence 1: NP_648590.1
• Gene: CG4069 / 39437
• FlyBaseID: FBgn0036301
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_060036.2
• Gene: KLHDC4 / 54758
• HGNCID: 25272
• Length: 520
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 214/524 - (40%)
• Similarity: 303/524 - (57%)
• Gaps: 32/524 - (6%)

  Fly     1 MGKKDKNKKKGKGAEKTAMKTDKKQAARQKKMLEKLGEANIADIIQLLEAKEGKIEAISESVCPP 65
            ||||.|.:|||:||||||.|.:||.:.|.:|..|.| ||.||. .|.|:||  :.:.: |..|||
Human     1 MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDL-EALIAH-FQTLDAK--RTQTV-ELPCPP 60

  Fly    66 PTPRSNFTLVCHPEKEELIMFGGELYTGTKTTVYNDLFFYNTKTVEWRQLKSPSGPTPRSGHQMV 130
            |:||.|.:|..||||:|||:||||.:.|.||.:||:|:.|||:...|.::..||.|..|..||.|
Human    61 PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAV 125

  Fly   131 AVASNGGELWMFGGEHASPSQLQFHHYKDLWKFALKSRKWERIAAPNGPSPRSGHRMTVSKKRLF 195
            .|...||:||:||||.|||:..||:||||||...|.::.||::.:..|||.||||||...|::|.
Human   126 VVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLI 190

  Fly   196 IFGGFHDNNQSYHYFNDVHIFSLESYQWLKAEIGGAIVPSPRSGCCIAASPEGKIYVWGGYSRAA 260
            :|||||::.:.|.|:|||:.|:|:::.|.|....|. .|:|||||.::.:|:|.|.|:||||:..
Human   191 LFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGT-GPTPRSGCQMSVTPQGGIVVYGGYSKQR 254

  Fly   261 MKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPKPRSSVGCTVAANGKAYTFGGVM 325
            :||:.|:|..|:|||:|..:....|   |:.|..:.|.|.||.|||.....:|.|.:...||||.
Human   255 VKKDVDKGTRHSDMFLLKPEDGRED---KWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVC 316

  Fly   326 DVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQTKSSSAEKKDSEESKDVEMSAVDKPV------ 384
            | :|::|.:.|:|.:||..:|.|...|  .|.|.|...:|||.....:..|.....:|.
Human   317 D-EEEEESLSGEFFNDLYFYDATRNRW--FEGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGT 378

  Fly   385 ---------TTTTDG-IFTV--TVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPGMCVCKGT 437
                     ....|| :.|:  .:..|.::..|......||.....|...|.||.|..:.|..|.
Human   379 QGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGV 443

  Fly   438 LYIFGGIFEEDDKQLTYNDFYALDLHKLE-WKVLIPNSLKGHEW-EDSDSSSSDEECSGSEEDIS 500
            ||::||:||..|:|:|.:|.:.||||::| ||.|:....:..|| |::||....||..|:|..:.
Human   444 LYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVD 508

  Fly   501 SSSS 504
            ...|
Human   509 DEDS 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	NanM	64..353	CDD:442289	132/288 (46%)
		KELCH repeat	69..120	CDD:276965	25/50 (50%)
		KELCH repeat	124..179	CDD:276965	27/54 (50%)
		KELCH repeat	305..353	CDD:276965	17/47 (36%)
		Kelch_5	423..463	CDD:433528	18/39 (46%)
		KELCH repeat	426..470	CDD:276965	21/44 (48%)
KLHDC4	NP_060036.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		19/31 (61%)
		NanM	59..342	CDD:442289	132/287 (46%)
		KELCH repeat	64..115	CDD:276965	25/50 (50%)
		Kelch 1	77..129		25/51 (49%)
		KELCH repeat	119..174	CDD:276965	27/54 (50%)
		Kelch 2	133..187		29/53 (55%)
		KELCH repeat	177..226	CDD:276965	22/48 (46%)
		Kelch 3	188..241		22/53 (42%)
		KELCH repeat	231..293	CDD:276965	26/64 (41%)
		Kelch 4	243..289		18/48 (38%)
		Kelch 5	308..361		20/55 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..379		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..431		6/28 (21%)
		KELCH repeat	432..480	CDD:276965	22/47 (47%)
		Kelch 6	443..494		22/50 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..520		10/32 (31%)