Protein Alignment CG4069 and KLHDC4

DIOPT Version :9

• Sequence 1: NP_648590.1
• Gene: CG4069 / 39437
• FlyBaseID: FBgn0036301
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_006721264.1
• Gene: KLHDC4 / 54758
• HGNCID: 25272
• Length: 525
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 214/529 - (40%)
• Similarity: 303/529 - (57%)
• Gaps: 37/529 - (6%)

  Fly     1 MGKKDKNKKKGKGAEKTAMKTDKKQAARQKKMLEKLGEANIADIIQLLEAKEGKIEAISESVCPP 65
            ||||.|.:|||:||||||.|.:||.:.|.:|..|.| ||.||. .|.|:||  :.:.: |..|||
Human     1 MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDL-EALIAH-FQTLDAK--RTQTV-ELPCPP 60

  Fly    66 PTPRSNFTLVCHPEKEELIMFGGELYTGTKTTVYNDLFFYNTKTVEWRQLKSPSGPTPRSGHQMV 130
            |:||.|.:|..||||:|||:||||.:.|.||.:||:|:.|||:...|.::..||.|..|..||.|
Human    61 PSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAV 125

  Fly   131 AVASNGGELWMFGGEHASPSQLQFHHYKDLWKFALKSRKWERI-----AAPNGPSPRSGHRMTVS 190
            .|...||:||:||||.|||:..||:||||||...|.::.||::     .:..|||.||||||...
Human   126 VVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVNLFHFRSTGGPSGRSGHRMVAW 190

  Fly   191 KKRLFIFGGFHDNNQSYHYFNDVHIFSLESYQWLKAEIGGAIVPSPRSGCCIAASPEGKIYVWGG 255
            |::|.:|||||::.:.|.|:|||:.|:|:::.|.|....|. .|:|||||.::.:|:|.|.|:||
Human   191 KRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGT-GPTPRSGCQMSVTPQGGIVVYGG 254

  Fly   256 YSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPKPRSSVGCTVAANGKAYT 320
            ||:..:||:.|:|..|:|||:|..:....|   |:.|..:.|.|.||.|||.....:|.|.:...
Human   255 YSKQRVKKDVDKGTRHSDMFLLKPEDGRED---KWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLF 316

  Fly   321 FGGVMDVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQTKSSSAEKKDSEESKDVEMSAVDKPV- 384
            ||||.| :|::|.:.|:|.:||..:|.|...|  .|.|.|...:|||.....:..|.....:|.
Human   317 FGGVCD-EEEEESLSGEFFNDLYFYDATRNRW--FEGQLKGPKSEKKKRRRGRKEEPEGGSRPAC 378

  Fly   385 --------------TTTTDG-IFTV--TVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPGMC 432
                          ....|| :.|:  .:..|.::..|......||.....|...|.||.|..:.
Human   379 GGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLA 443

  Fly   433 VCKGTLYIFGGIFEEDDKQLTYNDFYALDLHKLE-WKVLIPNSLKGHEW-EDSDSSSSDEECSGS 495
            |..|.||::||:||..|:|:|.:|.:.||||::| ||.|:....:..|| |::||....||..|:
Human   444 VKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGA 508

  Fly   496 EEDISSSSS 504
            |..:....|
Human   509 EGGVDDEDS 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	25/50 (50%)
		Kelch_3	80..132	CDD:290151	25/51 (49%)
		KELCH repeat	124..179	CDD:276965	27/59 (46%)
		Kelch_3	136..189	CDD:290151	31/57 (54%)
		Kelch_3	191..244	CDD:290151	23/52 (44%)
		Kelch_2	237..297	CDD:284956	24/59 (41%)
		KELCH repeat	305..353	CDD:276965	17/47 (36%)
		Kelch_5	423..463	CDD:290565	18/39 (46%)
		KELCH repeat	426..470	CDD:276965	21/44 (48%)
KLHDC4	XP_006721264.1	KELCH repeat	64..115	CDD:276965	25/50 (50%)
		PLN02193	<77..319	CDD:330882	109/245 (44%)
		KELCH repeat	119..179	CDD:276965	27/59 (46%)
		KELCH repeat	182..231	CDD:276965	22/48 (46%)
		KELCH repeat	236..298	CDD:276965	26/64 (41%)
		KELCH repeat	437..485	CDD:276965	22/47 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69234
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1997
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56581
OrthoDB	1	1.010	-	-		D359532at33208
OrthoFinder	1	1.000	-	-		FOG0006519
OrthoInspector	1	1.000	-	-		oto89911
orthoMCL	1	0.900	-	-		OOG6_103804
Panther	1	1.100	-	-	LDO	PTHR46063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	1	1.000	-	-		X5490
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800