DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4069 and Hcf

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	97/436 - (22%)
Similarity:	158/436 - (36%)	Gaps:	135/436 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PPPTPRSNFTLVCHPEKEELIMFGGELYTGTKTTVYNDLFFYNTKTVEWRQLKSPSGPTPRSGHQ 128
            |.|.||.....:  ..||.:::|||    |.:..| ::|..|||.|.:| .:....|..| :|..
  Fly    69 PQPRPRHGHRAI--NIKELMVVFGG----GNEGIV-DELHVYNTVTNQW-YVPVLKGDVP-NGCA 124

  Fly   129 MVAVASNGGELWMFGGEHASPSQLQFHHY-KDLWKFALKSRKWE-RIAAPNGPS------PRSGH 185
            .......|..:::|||      .:::..| .:|::  |::.||| |...|..|.      ||.||
  Fly   125 AYGFVVEGTRMFVFGG------MIEYGKYSNELYE--LQATKWEWRKMYPESPDSGLSPCPRLGH 181

  Fly   186 RMTVSKKRLFIFGGFHD-----NNQSYHYFNDVHIFSLESY-----QWLKAEIGGAIVPSPR--- 237
            ..|:..:::|:|||..:     .|....|.||::|......     :|:..:..|. .|.||
  Fly   182 SFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGD-SPPPRESH 245

  Fly   238 SGCCIAASPEG--KIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGY 300
            :|...|....|  .:.::||.|          |....|:::|..|        ...|:..|..|.
  Fly   246 TGISFATKSNGNLNLLIYGGMS----------GCRLGDLWLLETD--------SMTWSKPKTSGE 292

  Fly   301 KPKPRSSVGCTVAANGKAYTFGG----VMDVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQTKS 361
            .|.|||....|:..| |.|.|||    |::..:...:...:..:.|...||.:.||
  Fly   293 APLPRSLHSSTMIGN-KMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTW--------- 347

  Fly   362 SSAEKKDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPR 426
                       ::|.:..|::.|                                        ||
  Fly   348 -----------ENVTLDTVEENV----------------------------------------PR 361

  Fly   427 MNPGMCV--CKGTLYIFGGIFEED------DKQLTYNDFYALDLHK 464
            ...|.|.  .:..||::.|   .|      :.|:...|.:.|::.|
  Fly   362 ARAGHCAVGIQSRLYVWSG---RDGYRKAWNNQVCCKDLWYLEVSK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	14/50 (28%)
		Kelch_3	80..132	CDD:290151	16/51 (31%)
		KELCH repeat	124..179	CDD:276965	13/56 (23%)
		Kelch_3	136..189	CDD:290151	17/60 (28%)
		Kelch_3	191..244	CDD:290151	15/65 (23%)
		Kelch_2	237..297	CDD:284956	12/64 (19%)
		KELCH repeat	305..353	CDD:276965	14/51 (27%)
		Kelch_5	423..463	CDD:290565	11/47 (23%)
		KELCH repeat	426..470	CDD:276965	11/47 (23%)
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	14/43 (33%)
		KELCH repeat	74..115	CDD:276965	14/48 (29%)
		KELCH repeat	123..175	CDD:276965	13/59 (22%)
		Kelch_3	132..184	CDD:290151	17/59 (29%)
		Kelch_5	175..221	CDD:290565	14/45 (31%)
		KELCH repeat	178..239	CDD:276965	15/61 (25%)
		Kelch_3	260..305	CDD:290151	15/62 (24%)
		KELCH repeat	297..360	CDD:276965	18/123 (15%)
		Kelch_3	306..371	CDD:290151	19/125 (15%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870