DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4069 and rabepk

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001002209.1	Gene:	rabepk / 431756	ZFINID:	ZDB-GENE-040704-52	Length:	351	Species:	Danio rerio

Alignment Length:	292	Identity:	73/292 - (25%)
Similarity:	111/292 - (38%)	Gaps:	50/292 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HPE----KEELIMFGGELYTGTKTTVYNDLFFYNTKTVEWRQLKSPSGPTPRSGHQMVAVASNGG 137
            |.|    |.::::.||...:|:    :.|.:..|..|.:| .|....|...|..|......|...
Zfish    45 HDEDGGGKGKIVIVGGANPSGS----FADSYIINLDTHQW-DLPDWEGLQARYEHCSFTPESEPQ 104

  Fly   138 ELWMFGGEHASPSQ--LQFHHYKDLWKFALKSRKWERIAAPN-GPSPRSGHRMTVS-KKRLFIFG 198
            .||:|||...|.::  :|...:.|..:   ..|.|:.:.... .||.|:.|..:.. ..|||:|.
Zfish   105 SLWVFGGAEKSTNRNCVQALRFSDGGE---GRRFWQSVQVTGVPPSGRTYHTNSACVGNRLFVFS 166

  Fly   199 GFHDNNQSYHYFND--VHIFSLESYQWLKAEIGGAIVPSPRSGCCIAASPEGKIYVWGGYSRAAM 261
            |....:.:   ..|  :|:|...|..|.:.:..|. .|:.|.|..|.| ....||:.||.|....
Zfish   167 GGEAGSSA---VTDAQLHVFDAVSVTWTQPDTTGT-PPAQRHGHVITA-VGSDIYIHGGMSGEKF 226

  Fly   262 KKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPKPRSSVGCTVAANGKAYTFGGVMD 326
                     |:|||.|:.:        ..||..||..|..| |..:...:|..|...:.||| |.
Zfish   227 ---------HSDMFTLNTE--------SLKWQKVKAKGDLP-PGVAAHSSVTFNKNIFIFGG-MT 272

  Fly   327 VDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQ 358
            .|...        :.:..|....|.|.|.:.:
Zfish   273 ADGAT--------NSMFKFQCDKQRWTLLKFE 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	11/46 (24%)
		Kelch_3	80..132	CDD:290151	12/51 (24%)
		KELCH repeat	124..179	CDD:276965	13/57 (23%)
		Kelch_3	136..189	CDD:290151	14/55 (25%)
		Kelch_3	191..244	CDD:290151	15/54 (28%)
		Kelch_2	237..297	CDD:284956	17/59 (29%)
		KELCH repeat	305..353	CDD:276965	9/47 (19%)
		Kelch_5	423..463	CDD:290565
		KELCH repeat	426..470	CDD:276965
rabepk	NP_001002209.1	Kelch 1	54..102		11/52 (21%)
		Kelch 2	105..156		14/53 (26%)
		KELCH repeat	149..199	CDD:276965	13/53 (25%)
		Kelch_3	159..211	CDD:290151	16/56 (29%)
		Kelch 3	162..210		14/51 (27%)
		KELCH repeat	203..250	CDD:276965	19/64 (30%)
		Kelch_1	203..243	CDD:279660	16/57 (28%)
		Kelch 4	214..263		18/66 (27%)
		KELCH repeat	253..293	CDD:276965	10/48 (21%)
		Kelch_3	262..311	CDD:290151	10/44 (23%)
		Kelch 5	264..313		9/42 (21%)
		Kelch 6	328..351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940