DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4069 and Lztr1

DIOPT Version :9

Sequence 1:	NP_648590.1	Gene:	CG4069 / 39437	FlyBaseID:	FBgn0036301	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	91/374 - (24%)
Similarity:	144/374 - (38%)	Gaps:	80/374 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 TKTVEWRQLKSPSG--PTPRSGHQMVAVASNGGELWMFGGEHASPSQLQFHHYKDLWKFALKSRK 169
            |.|.:|.::...:.  ...||.|.:||...   .:::|||::..      :...||.:|.:|.:.
  Fly   233 TATHQWTRMLECAEFVGAKRSKHTVVAYKD---AMFVFGGDNGK------NMLNDLIRFGVKDKS 288

  Fly   170 WERIAAP-NGPSPRSGHRMTVSKKRLFIFGGF----HDNNQSYHYFNDVHIFSLESYQWLKAEIG 229
            |.|..|. ..|:||..|...|:...:|||||:    |.|:...:. ||:..:..:|..|::.:..
  Fly   289 WGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNK-NDLFEYKFQSAMWVEWKFS 352

  Fly   230 GAIVPSPRS--GCCIAASPEGKIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKW 292
            |. .|.|||  |   ||..:.|::::.||         |......||:.|       :...:.:|
  Fly   353 GR-QPVPRSAHG---AAVYDNKMWIYAGY---------DGNARLNDMWTL-------NLTGENQW 397

  Fly   293 APVKPGGYKPKPRSSVGCTVAANGKAYTFGGVMDVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEI 357
            ..|...|.:|....:....||.:. .|.|.|...:         |..:.|..|...::|||
  Fly   398 EEVDQLGDRPPTCCNFPVAVARDA-MYVFSGQSGL---------QITNSLFEFHFKTRTWR---- 448

  Fly   358 QTKSSSAEKKDSEESKDVEMSAVDKPV------TTTTDGIFTVTVGGPSTSTTP-------FVSK 409
                     :.|.|  .|...|...|.      |......|....||.:.||.|       ..|:
  Fly   449 ---------RISNE--PVLRGATSAPPSRRYGHTMVHHDRFLYVFGGSADSTLPNDLHCYDLDSQ 502

  Fly   410 IPSLFAKPKPTNVPSPRMNPGMCVCKGTLYIFGGIFEEDDKQLTYNDFY 458
            :.|:....:.::|||.|:.....|....:|||||..   |..:...|.|
  Fly   503 VWSVIQPEQNSDVPSGRVFHASAVICDAMYIFGGTV---DNSVRRGDTY 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4069	NP_648590.1	KELCH repeat	69..120	CDD:276965	3/12 (25%)
		Kelch_3	80..132	CDD:290151	7/26 (27%)
		KELCH repeat	124..179	CDD:276965	15/55 (27%)
		Kelch_3	136..189	CDD:290151	14/53 (26%)
		Kelch_3	191..244	CDD:290151	17/58 (29%)
		Kelch_2	237..297	CDD:284956	14/61 (23%)
		KELCH repeat	305..353	CDD:276965	9/47 (19%)
		Kelch_5	423..463	CDD:290565	12/36 (33%)
		KELCH repeat	426..470	CDD:276965	10/33 (30%)
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	89/370 (24%)
		KELCH repeat	252..298	CDD:276965	15/54 (28%)
		Kelch_3	261..310	CDD:290151	14/57 (25%)
		Kelch_5	299..>329	CDD:290565	12/29 (41%)
		KELCH repeat	302..355	CDD:276965	15/54 (28%)
		Kelch_1	358..400	CDD:279660	14/60 (23%)
		KELCH repeat	359..407	CDD:276965	15/66 (23%)
		KELCH repeat	410..455	CDD:276965	13/69 (19%)
		Kelch_1	410..452	CDD:279660	11/64 (17%)
		Kelch_1	466..509	CDD:279660	9/42 (21%)
		KELCH repeat	467..509	CDD:276965	9/41 (22%)
		BTB	564..704	CDD:279045
		BTB	575..707	CDD:197585
		SPOP_C_like	707..766	CDD:269810
		BTB	798..898	CDD:279045
		BTB	802..902	CDD:197585
		SPOP_C_like	902..960	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.870