DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4069 and KLHDC2

DIOPT Version :10

Sequence 1:NP_648590.1 Gene:CG4069 / 39437 FlyBaseID:FBgn0036301 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_055130.1 Gene:KLHDC2 / 23588 HGNCID:20231 Length:406 Species:Homo sapiens


Alignment Length:320 Identity:75/320 - (23%)
Similarity:118/320 - (36%) Gaps:78/320 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 PSPRSGHRMTVSKKRLFIFGGFHDNNQS--YHYF---NDVHIFSLESYQWLKAEIGGAIVPSPRS 238
            |:.||||......:.:|::||:..|...  |.::   .::.|:::|:.:|.|....|.:.||...
Human    29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSG 93

  Fly   239 GCCIAASPEGKIYVWGGYSRAAMKKEADRGVTHTDMFVLSQDKNAGDADNKYKWAPVKPGGYKPK 303
            .|.:..  :..:|::||:.        .||  :|:.|.:...::   .|...:|..:...|..|.
Human    94 SCAVCV--DRVLYLFGGHH--------SRG--NTNKFYMLDSRS---TDRVLQWERIDCQGIPPS 143

  Fly   304 PRSSVGCTVAANGKAYTFGGVMDVDEDDEDVHGQFGDDLLAFDLTSQTWRLQEIQTKSSSAEK-- 366
            .:..:|..|..| |...|||...:.||  .|.|.|     .||.|| .|        :||..:  
Human   144 SKDKLGVWVYKN-KLIFFGGYGYLPED--KVLGTF-----EFDETS-FW--------NSSHPRGW 191

  Fly   367 KDSEESKDVEMSAVDKPVTTTTDGIFTVTVGGPSTSTTPFVSKIPSLFAKPKPTNVPSPRMNPGM 431
            .|.....|.|.....:|:||                                 ...||||.....
Human   192 NDHVHILDTETFTWSQPITT---------------------------------GKAPSPRAAHAC 223

  Fly   432 CVCKGTLYIFGGIFEEDDKQLTYNDFYALDLHKLEWKVLIPNSL--KGHEWEDSDSSSSD 489
            .......::|||.:    :....||.:.|:|...||..|||..:  .|..|......|||
Human   224 ATVGNRGFVFGGRY----RDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSD 279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4069NP_648590.1 NanM 64..353 CDD:442289 45/178 (25%)
KELCH repeat 69..120 CDD:276965
KELCH repeat 124..179 CDD:276965 75/320 (23%)
KELCH repeat 305..353 CDD:276965 16/47 (34%)
Kelch_5 423..463 CDD:433528 10/39 (26%)
KELCH repeat 426..470 CDD:276965 10/43 (23%)
KLHDC2NP_055130.1 Kelch 1. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 31..85 13/53 (25%)
KELCH repeat 32..91 CDD:276965 15/58 (26%)
Kelch_4 32..89 CDD:433191 14/56 (25%)
NanM 78..>337 CDD:442289 63/271 (23%)
KELCH repeat 92..138 CDD:276965 10/60 (17%)
Kelch 2. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 92..136 10/58 (17%)
Kelch 3. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 148..207 22/75 (29%)
KELCH repeat 218..265 CDD:276965 13/50 (26%)
Kelch 4. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 221..259 9/41 (22%)
Kelch 5. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 271..311 3/9 (33%)
Kelch 6. /evidence=ECO:0000269|PubMed:36805027, ECO:0000269|PubMed:38177675, ECO:0007744|PDB:8EBL, ECO:0007744|PDB:8SGE, ECO:0007744|PDB:8SGF, ECO:0007744|PDB:8SH2 322..359
Blue background indicates that the domain is not in the aligned region.

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